GO Annotations Graph

• Symbol: Wfs1
• Name: wolframin ER transmembrane glycoprotein
• ID: MGI:1328355

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0051117	ATPase binding	IDA	J:135559
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	ISO	J:155856
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0070628	proteasome binding	ISO	J:155856
Molecular Function	GO:0045182	translation regulator activity	IMP	J:171795
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:172997
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0030141	secretory granule	ISO	J:164563
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Biological Process	GO:0055074	calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0055074	calcium ion homeostasis	IBA	J:265628
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IMP	J:109537
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IBA	J:265628
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IMP	J:171795
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	TAS	J:171795
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0001822	kidney development	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:1903892	negative regulation of ATF6-mediated unfolded protein response	ISO	J:155856
Biological Process	GO:1903892	negative regulation of ATF6-mediated unfolded protein response	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP	J:109537
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0043069	negative regulation of programmed cell death	ISO	J:164563
Biological Process	GO:1903573	negative regulation of response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0017148	negative regulation of translation	IMP	J:171795
Biological Process	GO:0017148	negative regulation of translation	TAS	J:171795
Biological Process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	ISO	J:164563
Biological Process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	IMP	J:109537
Biological Process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	IMP	J:172997
Biological Process	GO:0050877	nervous system process	ISO	J:164563
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:1904294	positive regulation of ERAD pathway	IMP	J:171795
Biological Process	GO:1904294	positive regulation of ERAD pathway	TAS	J:171795
Biological Process	GO:0045927	positive regulation of growth	IMP	J:157967
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IMP	J:172947
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	IMP	J:172947
Biological Process	GO:0050821	protein stabilization	ISO	J:155856
Biological Process	GO:0051726	regulation of cell cycle	NAS	J:109537
Biological Process	GO:0003091	renal water homeostasis	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:173000
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0007605	sensory perception of sound	ISO	J:164563
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	IMP	J:172947
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	ISO	J:164563
Biological Process	GO:0007601	visual perception	NAS	J:173746
Biological Process	GO:0007601	visual perception	ISO	J:164563