GO Annotations Graph

• Symbol: Smad5
• Name: SMAD family member 5
• ID: MGI:1328787

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:199979
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:100763
Molecular Function	GO:0005515	protein binding	IPI	J:106894
Molecular Function	GO:0005515	protein binding	IPI	J:170631
Molecular Function	GO:0005515	protein binding	IPI	J:93345
Molecular Function	GO:0005515	protein binding	IPI	J:79484
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:142136
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:242478
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:151027
Cellular Component	GO:0005737	cytoplasm	IDA	J:145723
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:151027
Cellular Component	GO:0005634	nucleus	IDA	J:116258
Cellular Component	GO:0005634	nucleus	IDA	J:153961
Cellular Component	GO:0005634	nucleus	IDA	J:145723
Cellular Component	GO:0032991	protein-containing complex	ISO	J:198828
Cellular Component	GO:0005667	transcription regulator complex	IEA	J:72247
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:196266
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:151027
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:147287
Biological Process	GO:0030509	BMP signaling pathway	TAS	J:79484
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:147287
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:138713
Biological Process	GO:0060348	bone development	IGI	J:147287
Biological Process	GO:0060348	bone development	IGI	J:147287
Biological Process	GO:0060048	cardiac muscle contraction	IMP	J:121072
Biological Process	GO:0051216	cartilage development	IGI	J:147287
Biological Process	GO:0051216	cartilage development	IGI	J:147287
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0071773	cellular response to BMP stimulus	IGI	J:196266
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:145723
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:98445
Biological Process	GO:0007281	germ cell development	IMP	J:70069
Biological Process	GO:0001880	Mullerian duct regression	ISO	J:155856
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:1902045	negative regulation of Fas signaling pathway	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:199979
Biological Process	GO:0002051	osteoblast fate commitment	IGI	J:93345
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IGI	J:93345
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:96487
Biological Process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	IGI	J:196266
Biological Process	GO:0006468	protein phosphorylation	IDA	J:138769
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0060395	SMAD protein signal transduction	IGI	J:151027
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:69633
Biological Process	GO:0001657	ureteric bud development	IEP	J:95433