GO Annotations Graph

• Symbol: Dkk1
• Name: dickkopf WNT signaling pathway inhibitor 1
• ID: MGI:1329040

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0039706	co-receptor binding	ISO	J:164563
Molecular Function	GO:0039706	co-receptor binding	IBA	J:265628
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:103781
Molecular Function	GO:0005515	protein binding	IPI	J:101423
Molecular Function	GO:0005515	protein binding	IPI	J:101423
Molecular Function	GO:0048019	receptor antagonist activity	ISO	J:164563
Molecular Function	GO:0048019	receptor antagonist activity	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	ISS	J:57798
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:103781
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:134688
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:134688
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	IMP	J:134688
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:92327
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:92327
Biological Process	GO:0007492	endoderm development	IMP	J:134688
Biological Process	GO:0001706	endoderm formation	IDA	J:155850
Biological Process	GO:0060325	face morphogenesis	IMP	J:124680
Biological Process	GO:0030900	forebrain development	IGI	J:119933
Biological Process	GO:0001942	hair follicle development	IDA	J:110268
Biological Process	GO:0060323	head morphogenesis	IGI	J:134688
Biological Process	GO:0007611	learning or memory	IDA	J:241059
Biological Process	GO:0060173	limb development	IMP	J:137914
Biological Process	GO:0001707	mesoderm formation	IDA	J:155850
Biological Process	GO:0061743	motor learning	IDA	J:225337
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:240374
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IDA	J:157031
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:228115
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:225337
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:239208
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:120067
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:160170
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:160170
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:73065
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:91019
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:117476
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:124891
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IMP	J:134688
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:134688
Biological Process	GO:1901296	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	ISO	J:164563
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	ISO	J:164563
Biological Process	GO:0042662	negative regulation of mesodermal cell fate specification	ISO	J:164563
Biological Process	GO:0010977	negative regulation of neuron projection development	IDA	J:269539
Biological Process	GO:0030279	negative regulation of ossification	ISO	J:155856
Biological Process	GO:0030279	negative regulation of ossification	IMP	J:137914
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:1905607	negative regulation of presynapse assembly	IDA	J:269539
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:168283
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117476
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117476
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117476
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:157031
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:124680
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:158579
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:101423
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:155850
Biological Process	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	ISO	J:164563
Biological Process	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	TAS	J:225337
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:241059
Biological Process	GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway	IDA	J:145669
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:1904958	positive regulation of midbrain dopaminergic neuron differentiation	IMP	J:171097
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:1902949	positive regulation of tau-protein kinase activity	IDA	J:241059
Biological Process	GO:0042663	regulation of endodermal cell fate specification	ISO	J:164563
Biological Process	GO:0002090	regulation of receptor internalization	ISO	J:164563
Biological Process	GO:0050807	regulation of synapse organization	IDA	J:225337
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	IDA	J:225337
Biological Process	GO:0030111	regulation of Wnt signaling pathway	IMP	J:119933
Biological Process	GO:0032526	response to retinoic acid	IDA	J:118503
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:155850
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:158579
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:158579
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IGI	J:135313
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IGI	J:135313