GO Annotations Graph

• Symbol: Dyrk1a
• Name: dual-specificity tyrosine phosphorylation regulated kinase 1a
• ID: MGI:1330299

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:164563
Molecular Function	GO:0140857	histone H3T45 kinase activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:178153
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:38630
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:50326
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:178153
Molecular Function	GO:0005515	protein binding	IPI	J:165940
Molecular Function	GO:0005515	protein binding	IPI	J:161722
Molecular Function	GO:0005515	protein binding	IPI	J:183209
Molecular Function	GO:0005515	protein binding	IPI	J:182960
Molecular Function	GO:0005515	protein binding	IPI	J:91599
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0043621	protein self-association	IPI	J:38630
Molecular Function	GO:0106310	protein serine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:183209
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:161722
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IGI	J:128996
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	ISO	J:164563
Molecular Function	GO:0048156	tau protein binding	IPI	J:128996
Molecular Function	GO:0048156	tau protein binding	IPI	J:183209
Molecular Function	GO:0003713	transcription coactivator activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0015631	tubulin binding	ISO	J:164563
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0030424	axon	IDA	J:182785
Cellular Component	GO:0005737	cytoplasm	IDA	J:182785
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IDA	J:252003
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IDA	J:182785
Cellular Component	GO:0005874	microtubule	ISO	J:164563
Cellular Component	GO:0005883	neurofilament	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:38630
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:182785
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:1990904	ribonucleoprotein complex	IDA	J:174389
Biological Process	GO:0034205	amyloid-beta formation	ISO	J:164563
Biological Process	GO:0007623	circadian rhythm	IMP	J:161722
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA	J:183209
Biological Process	GO:0090310	negative regulation of DNA methylation-dependent heterochromatin formation	ISO	J:164563
Biological Process	GO:0031115	negative regulation of microtubule polymerization	IDA	J:128996
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	IMP	J:182960
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:161722
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:155856
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:183209
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IBA	J:265628
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	IDA	J:252003
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:50326
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:182960
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:0090312	positive regulation of protein deacetylation	IDA	J:183209
Biological Process	GO:0033120	positive regulation of RNA splicing	ISO	J:155856
Biological Process	GO:0033120	positive regulation of RNA splicing	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	ISO	J:155856