GO Annotations Graph

• Symbol: Arg2
• Name: arginase type II
• ID: MGI:1330806

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004053	arginase activity	ISO	J:155856
Molecular Function	GO:0004053	arginase activity	ISO	J:164563
Molecular Function	GO:0004053	arginase activity	IBA	J:265628
Molecular Function	GO:0004053	arginase activity	ISO	J:107662
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	IEA	J:72247
Molecular Function	GO:0030145	manganese ion binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0050998	nitric-oxide synthase binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:243479
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:107662
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0019547	arginine catabolic process to ornithine	ISO	J:155856
Biological Process	GO:0019547	arginine catabolic process to ornithine	IBA	J:265628
Biological Process	GO:0006525	arginine metabolic process	ISO	J:155856
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:1905403	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process	IMP	J:243512
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP	J:243479
Biological Process	GO:0071644	negative regulation of chemokine (C-C motif) ligand 4 production	IMP	J:243519
Biological Process	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	IMP	J:243519
Biological Process	GO:1900425	negative regulation of defense response to bacterium	IMP	J:243519
Biological Process	GO:0032696	negative regulation of interleukin-13 production	IMP	J:237069
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IMP	J:237069
Biological Process	GO:0071641	negative regulation of macrophage inflammatory protein 1 alpha production	IMP	J:243519
Biological Process	GO:0051001	negative regulation of nitric-oxide synthase activity	ISO	J:155856
Biological Process	GO:0045988	negative regulation of striated muscle contraction	ISO	J:155856
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:243519
Biological Process	GO:0002829	negative regulation of type 2 immune response	IMP	J:237069
Biological Process	GO:2000774	positive regulation of cellular senescence	ISO	J:164563
Biological Process	GO:0032651	regulation of interleukin-1 beta production	IMP	J:243519
Biological Process	GO:1905541	regulation of L-arginine import across plasma membrane	ISO	J:155856
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	IMP	J:237069
Biological Process	GO:0006941	striated muscle contraction	IMP	J:107662
Biological Process	GO:0000050	urea cycle	IEA	J:60000
Biological Process	GO:0001657	ureteric bud development	IEP	J:112220