GO Annotations Graph

• Symbol: Mapkapk5
• Name: MAP kinase-activated protein kinase 5
• ID: MGI:1333110

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0009931	calcium-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0005516	calmodulin binding	IBA	J:265628
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	IPI	J:180476
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	IPI	J:180468
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002039	p53 binding	IDA	J:117893
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:180541
Molecular Function	GO:0005515	protein binding	IPI	J:185814
Molecular Function	GO:0005515	protein binding	IPI	J:94780
Molecular Function	GO:0005515	protein binding	IPI	J:185814
Molecular Function	GO:0004672	protein kinase activity	IDA	J:185814
Molecular Function	GO:0004672	protein kinase activity	IDA	J:94780
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:117893
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:180549
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:180468
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:180476
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:180541
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:185814
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:180549
Cellular Component	GO:0005737	cytoplasm	IDA	J:180476
Cellular Component	GO:0005737	cytoplasm	IDA	J:180468
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:94780
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:180476
Cellular Component	GO:0005634	nucleus	IDA	J:180549
Cellular Component	GO:0005634	nucleus	IDA	J:180468
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:94780
Cellular Component	GO:0032991	protein-containing complex	IDA	J:185814
Cellular Component	GO:0032156	septin cytoskeleton	IDA	J:185814
Biological Process	GO:0032007	negative regulation of TOR signaling	IDA	J:180541
Biological Process	GO:0032007	negative regulation of TOR signaling	IBA	J:265628
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0060999	positive regulation of dendritic spine development	IMP	J:185814
Biological Process	GO:0060999	positive regulation of dendritic spine development	IGI	J:185814
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:1904355	positive regulation of telomere capping	ISO	J:164563
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0007265	Ras protein signal transduction	ISO	J:164563
Biological Process	GO:0007265	Ras protein signal transduction	IMP	J:117893
Biological Process	GO:0007265	Ras protein signal transduction	IBA	J:265628
Biological Process	GO:0006417	regulation of translation	ISO	J:164563
Biological Process	GO:0090400	stress-induced premature senescence	IMP	J:117893
Biological Process	GO:0090400	stress-induced premature senescence	ISO	J:164563