GO Annotations Graph

• Symbol: Hdac6
• Name: histone deacetylase 6
• ID: MGI:1333752

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0043014	alpha-tubulin binding	ISO	J:164563
Molecular Function	GO:0043014	alpha-tubulin binding	IDA	J:182257
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0048487	beta-tubulin binding	IDA	J:82250
Molecular Function	GO:0070840	dynein complex binding	ISO	J:164563
Molecular Function	GO:0004407	histone deacetylase activity	IMP	J:215334
Molecular Function	GO:0004407	histone deacetylase activity	IBA	J:265628
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:73065
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:72860
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:52197
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	IDA	J:163064
Molecular Function	GO:0008017	microtubule binding	ISO	J:164563
Molecular Function	GO:0051787	misfolded protein binding	ISO	J:164563
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:238090
Molecular Function	GO:0005515	protein binding	IPI	J:217945
Molecular Function	GO:0005515	protein binding	IPI	J:279931
Molecular Function	GO:0005515	protein binding	IPI	J:163064
Molecular Function	GO:0005515	protein binding	IPI	J:181967
Molecular Function	GO:0005515	protein binding	IPI	J:182257
Molecular Function	GO:0005515	protein binding	IPI	J:72860
Molecular Function	GO:0005515	protein binding	IPI	J:72860
Molecular Function	GO:0005515	protein binding	IPI	J:189648
Molecular Function	GO:0005515	protein binding	IPI	J:205987
Molecular Function	GO:0033558	protein lysine deacetylase activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0048156	tau protein binding	IPI	J:257316
Molecular Function	GO:0048156	tau protein binding	ISO	J:164563
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IBA	J:265628
Molecular Function	GO:0042903	tubulin deacetylase activity	ISO	J:164563
Molecular Function	GO:0042903	tubulin deacetylase activity	IMP	J:257316
Molecular Function	GO:0042903	tubulin deacetylase activity	IGI	J:259116
Molecular Function	GO:0042903	tubulin deacetylase activity	IDA	J:163064
Molecular Function	GO:0042903	tubulin deacetylase activity	ISO	J:182257
Molecular Function	GO:0042903	tubulin deacetylase activity	IDA	J:82250
Molecular Function	GO:0043130	ubiquitin binding	IDA	J:72860
Molecular Function	GO:0043130	ubiquitin binding	IDA	J:111173
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0016235	aggresome	ISO	J:164563
Cellular Component	GO:0030424	axon	IDA	J:209487
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0031252	cell leading edge	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0036064	ciliary basal body	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:182257
Cellular Component	GO:0005737	cytoplasm	IDA	J:72860
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:163064
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9646345
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9646359
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9646393
Cellular Component	GO:0030425	dendrite	IDA	J:209487
Cellular Component	GO:0000118	histone deacetylase complex	ISO	J:164563
Cellular Component	GO:0000118	histone deacetylase complex	IBA	J:265628
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Cellular Component	GO:0005874	microtubule	ISO	J:164563
Cellular Component	GO:0005875	microtubule associated complex	ISO	J:164563
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:82250
Cellular Component	GO:0043005	neuron projection	IDA	J:205987
Cellular Component	GO:0043025	neuronal cell body	IDA	J:205987
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:163064
Cellular Component	GO:0005634	nucleus	TAS	J:80835
Cellular Component	GO:0043204	perikaryon	IDA	J:209487
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:182257
Cellular Component	GO:0032991	protein-containing complex	IPI	J:125219
Cellular Component	GO:0032991	protein-containing complex	IPI	J:125219
Biological Process	GO:0070842	aggresome assembly	ISO	J:164563
Biological Process	GO:0070842	aggresome assembly	IGI	J:111173
Biological Process	GO:0019896	axonal transport of mitochondrion	ISO	J:164563
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0071218	cellular response to misfolded protein	IMP	J:125219
Biological Process	GO:0035967	cellular response to topologically incorrect protein	ISO	J:164563
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0061523	cilium disassembly	ISO	J:164563
Biological Process	GO:0048668	collateral sprouting	IMP	J:205987
Biological Process	GO:0060997	dendritic spine morphogenesis	IMP	J:205987
Biological Process	GO:0040029	epigenetic regulation of gene expression	ISO	J:164563
Biological Process	GO:0016575	histone deacetylation	ISO	J:164563
Biological Process	GO:0016575	histone deacetylation	IBA	J:265628
Biological Process	GO:0070846	Hsp90 deacetylation	IMP	J:125219
Biological Process	GO:0006886	intracellular protein transport	ISO	J:164563
Biological Process	GO:0032418	lysosome localization	ISO	J:164563
Biological Process	GO:0051646	mitochondrion localization	IMP	J:217987
Biological Process	GO:0014902	myotube differentiation	IMP	J:182257
Biological Process	GO:0014902	myotube differentiation	ISO	J:182257
Biological Process	GO:0007026	negative regulation of microtubule depolymerization	IDA	J:80835
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0043242	negative regulation of protein-containing complex disassembly	ISO	J:164563
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	ISO	J:164563
Biological Process	GO:0034983	peptidyl-lysine deacetylation	ISO	J:164563
Biological Process	GO:0034983	peptidyl-lysine deacetylation	IMP	J:255331
Biological Process	GO:0070845	polyubiquitinated misfolded protein transport	ISO	J:164563
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	ISO	J:164563
Biological Process	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	IGI	J:217987
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IMP	J:255331
Biological Process	GO:2000273	positive regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	IDA	J:80835
Biological Process	GO:0031648	protein destabilization	IMP	J:215334
Biological Process	GO:0000209	protein polyubiquitination	IDA	J:72860
Biological Process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	ISO	J:164563
Biological Process	GO:0032984	protein-containing complex disassembly	IGI	J:125219
Biological Process	GO:0032984	protein-containing complex disassembly	IGI	J:125219
Biological Process	GO:0070201	regulation of establishment of protein localization	IMP	J:189648
Biological Process	GO:0045598	regulation of fat cell differentiation	IMP	J:193991
Biological Process	GO:0016241	regulation of macroautophagy	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0070848	response to growth factor	ISO	J:164563
Biological Process	GO:0051788	response to misfolded protein	ISO	J:164563
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:182257
Biological Process	GO:0007519	skeletal muscle tissue development	ISO	J:182257
Biological Process	GO:0090042	tubulin deacetylation	ISO	J:164563
Biological Process	GO:0090042	tubulin deacetylation	IDA	J:163064
Biological Process	GO:0090042	tubulin deacetylation	ISO	J:182257
Biological Process	GO:0090042	tubulin deacetylation	IMP	J:82250
Biological Process	GO:0090042	tubulin deacetylation	IMP	J:111173
Biological Process	GO:0090042	tubulin deacetylation	IMP	J:125219
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP	J:111173
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IGI	J:111173
Biological Process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP	J:125219