GO Annotations Graph

• Symbol: Pld3
• Name: phospholipase D family member 3
• ID: MGI:1333782

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0004527	exonuclease activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0004630	phospholipase D activity	TAS	Reactome:R-MMU-1483172
Molecular Function	GO:0004630	phospholipase D activity	ISS	J:51052
Molecular Function	GO:0045145	single-stranded DNA 5'-3' DNA exonuclease activity	IDA	J:281205
Molecular Function	GO:0045145	single-stranded DNA 5'-3' DNA exonuclease activity	ISO	J:164563
Cellular Component	GO:0031901	early endosome membrane	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TAS	Reactome:R-MMU-1483172
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0031902	late endosome membrane	ISO	J:164563
Cellular Component	GO:0031902	late endosome membrane	IDA	J:256592
Cellular Component	GO:0043202	lysosomal lumen	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	IDA	J:256592
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISS	J:51052
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0014902	myotube differentiation	ISO	J:164563
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	IMP	J:180963