GO Annotations Graph

• Symbol: Hdac5
• Name: histone deacetylase 5
• ID: MGI:1333784

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:172910
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	TAS	J:113927
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	J:158762
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:164563
Molecular Function	GO:0004407	histone deacetylase activity	TAS	J:113927
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:189792
Molecular Function	GO:0005515	protein binding	IPI	J:169070
Molecular Function	GO:0005515	protein binding	IPI	J:248212
Molecular Function	GO:0005515	protein binding	IPI	J:114106
Molecular Function	GO:0005515	protein binding	IPI	J:99840
Molecular Function	GO:0005515	protein binding	IPI	J:64684
Molecular Function	GO:0005515	protein binding	IPI	J:95385
Molecular Function	GO:0005515	protein binding	IPI	J:99840
Molecular Function	GO:0005515	protein binding	IPI	J:136003
Molecular Function	GO:0005515	protein binding	IPI	J:72326
Molecular Function	GO:0005515	protein binding	IPI	J:102395
Molecular Function	GO:0019901	protein kinase binding	IPI	J:121892
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:164563
Molecular Function	GO:0033558	protein lysine deacetylase activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:158762
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:161725
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:64684
Molecular Function	GO:0003714	transcription corepressor activity	IGI	J:99840
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Molecular Function	GO:0001222	transcription corepressor binding	IPI	J:76061
Cellular Component	GO:0044295	axonal growth cone	IDA	J:281211
Cellular Component	GO:0000785	chromatin	IDA	J:76061
Cellular Component	GO:0005737	cytoplasm	TAS	J:113927
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:121892
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:161038
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:136003
Cellular Component	GO:0005829	cytosol	IDA	J:133573
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0000118	histone deacetylase complex	TAS	J:113927
Cellular Component	GO:0016604	nuclear body	IDA	J:72326
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	TAS	J:113927
Cellular Component	GO:0005634	nucleus	IDA	J:121892
Cellular Component	GO:0005634	nucleus	IDA	J:158762
Cellular Component	GO:0005634	nucleus	IDA	J:133573
Cellular Component	GO:0005634	nucleus	IDA	J:161038
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0090571	RNA polymerase II transcription repressor complex	IDA	J:76061
Biological Process	GO:0042113	B cell activation	TAS	J:113927
Biological Process	GO:0030183	B cell differentiation	TAS	J:113927
Biological Process	GO:0071498	cellular response to fluid shear stress	IDA	J:158762
Biological Process	GO:0006325	chromatin organization	TAS	J:113927
Biological Process	GO:0040029	epigenetic regulation of gene expression	ISO	J:164563
Biological Process	GO:0007507	heart development	IGI	J:93021
Biological Process	GO:0016575	histone deacetylation	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	TAS	J:113927
Biological Process	GO:0033555	multicellular organismal response to stress	IMP	J:132207
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TAS	J:113927
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:102395
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:210206
Biological Process	GO:0010832	negative regulation of myotube differentiation	ISO	J:164563
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IMP	J:99840
Biological Process	GO:0045843	negative regulation of striated muscle tissue development	TAS	J:113927
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:158762
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:149882
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:99840
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:210206
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:95385
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:64684
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:149882
Biological Process	GO:0007399	nervous system development	TAS	J:113927
Biological Process	GO:0002076	osteoblast development	IMP	J:99840
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:99840
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	IMP	J:161725
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:161725
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	ISO	J:164563
Biological Process	GO:0010830	regulation of myotube differentiation	IDA	J:121892
Biological Process	GO:0043393	regulation of protein binding	ISO	J:164563
Biological Process	GO:0048742	regulation of skeletal muscle fiber development	IGI	J:127416
Biological Process	GO:0048742	regulation of skeletal muscle fiber development	IGI	J:127416
Biological Process	GO:1902809	regulation of skeletal muscle fiber differentiation	IGI	J:127416
Biological Process	GO:1902809	regulation of skeletal muscle fiber differentiation	IGI	J:127416
Biological Process	GO:0061333	renal tubule morphogenesis	IMP	J:158762
Biological Process	GO:0042220	response to cocaine	IDA	J:132207
Biological Process	GO:0042220	response to cocaine	IMP	J:132207
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856