Xrcc4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
MGI:1333799

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity	IMP	J:125414
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0070975	FHA domain binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:125414
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0032807	DNA ligase IV complex	ISO	J:164563
Cellular Component	GO:0032807	DNA ligase IV complex	IBA	J:265628
Cellular Component	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	IBA	J:265628
Cellular Component	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	IDA	J:92391
Cellular Component	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	ISO	J:73065
Cellular Component	GO:0070522	ERCC4-ERCC1 complex	IDA	J:125414
Cellular Component	GO:0070419	nonhomologous end joining complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Biological Process	GO:0007417	central nervous system development	IMP	J:65218
Biological Process	GO:1904155	DN2 thymocyte differentiation	IMP	J:65218
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006266	DNA ligation	IDA	J:92391
Biological Process	GO:0051103	DNA ligation involved in DNA repair	ISO	J:164563
Biological Process	GO:0051103	DNA ligation involved in DNA repair	IBA	J:265628
Biological Process	GO:0006310	DNA recombination	IEA	J:72247
Biological Process	GO:0006310	DNA recombination	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	IMP	J:73443
Biological Process	GO:0006302	double-strand break repair	IMP	J:65218
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IMP	J:125414
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IBA	J:265628
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IMP	J:126758
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:65218
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	IBA	J:265628
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	IMP	J:65218
Biological Process	GO:0001701	in utero embryonic development	IMP	J:65218
Biological Process	GO:0045190	isotype switching	IMP	J:126758
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:65218
Biological Process	GO:1905765	negative regulation of protection from non-homologous end joining at telomere	IMP	J:125414
Biological Process	GO:0022008	neurogenesis	IMP	J:65218
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:65218
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:65218
Biological Process	GO:0051351	positive regulation of ligase activity	ISO	J:164563
Biological Process	GO:0051351	positive regulation of ligase activity	IBA	J:265628
Biological Process	GO:0050769	positive regulation of neurogenesis	IMP	J:65218
Biological Process	GO:1905782	positive regulation of phosphatidylserine exposure on apoptotic cell surface	ISO	J:164563
Biological Process	GO:0002328	pro-B cell differentiation	IMP	J:65218
Biological Process	GO:1990166	protein localization to site of double-strand break	ISO	J:164563
Biological Process	GO:0010332	response to gamma radiation	IMP	J:65218
Biological Process	GO:0010212	response to ionizing radiation	IMP	J:126758
Biological Process	GO:0010165	response to X-ray	ISO	J:164563
Biological Process	GO:0010165	response to X-ray	IBA	J:265628
Biological Process	GO:0010165	response to X-ray	IMP	J:65218
Biological Process	GO:0061819	telomeric DNA-containing double minutes formation	IMP	J:125414
Biological Process	GO:0033151	V(D)J recombination	IMP	J:110848

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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