GO Annotations Graph

• Symbol: Mbd3
• Name: methyl-CpG binding domain protein 3
• ID: MGI:1333812

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:104088
Molecular Function	GO:0003677	DNA binding	IDA	J:50520
Molecular Function	GO:0008327	methyl-CpG binding	ISO	J:164563
Molecular Function	GO:0008327	methyl-CpG binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:138367
Molecular Function	GO:0005515	protein binding	IPI	J:138367
Molecular Function	GO:0005515	protein binding	IPI	J:106974
Molecular Function	GO:0005515	protein binding	IPI	J:227373
Molecular Function	GO:0005515	protein binding	IPI	J:106974
Molecular Function	GO:0005515	protein binding	IPI	J:104088
Molecular Function	GO:0005515	protein binding	IPI	J:106974
Cellular Component	GO:0000785	chromatin	IDA	J:50520
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:130115
Cellular Component	GO:0000792	heterochromatin	IDA	J:86958
Cellular Component	GO:0000792	heterochromatin	IDA	J:86958
Cellular Component	GO:0000792	heterochromatin	IDA	J:104088
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-573373
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-573385
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:86958
Cellular Component	GO:0005634	nucleus	IDA	J:168362
Cellular Component	GO:0005634	nucleus	IDA	J:130115
Cellular Component	GO:0005634	nucleus	IDA	J:50520
Cellular Component	GO:0005634	nucleus	IDA	J:118937
Cellular Component	GO:0005634	nucleus	IDA	J:86958
Cellular Component	GO:0005634	nucleus	IDA	J:227373
Cellular Component	GO:0005634	nucleus	IDA	J:118937
Cellular Component	GO:0016581	NuRD complex	NAS	J:319987
Cellular Component	GO:0016581	NuRD complex	ISO	J:164563
Cellular Component	GO:0016581	NuRD complex	IPI	J:106974
Cellular Component	GO:0016581	NuRD complex	IPI	J:106974
Cellular Component	GO:0016581	NuRD complex	IPI	J:106974
Cellular Component	GO:0032991	protein-containing complex	IDA	J:154112
Biological Process	GO:0006338	chromatin remodeling	ISO	J:164563
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	IBA	J:265628
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	IDA	J:104088
Biological Process	GO:0016573	histone acetylation	IMP	J:106974
Biological Process	GO:0016575	histone deacetylation	ISO	J:164563
Biological Process	GO:0001701	in utero embryonic development	IMP	J:118937
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NAS	J:319679
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:104088
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NAS	J:156393
Biological Process	GO:0042659	regulation of cell fate specification	NAS	J:319679
Biological Process	GO:2000736	regulation of stem cell differentiation	NAS	J:319679
Biological Process	GO:0009888	tissue development	IMP	J:118937
Biological Process	GO:0009888	tissue development	IMP	J:118937