Cx3cr1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cx3cr1
C-X3-C motif chemokine receptor 1
MGI:1333815

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019960	C-X3-C chemokine binding	IPI	J:263697
Molecular Function	GO:0019960	C-X3-C chemokine binding	ISO	J:164563
Molecular Function	GO:0016495	C-X3-C chemokine receptor activity	ISO	J:164563
Molecular Function	GO:0016495	C-X3-C chemokine receptor activity	ISO	J:155856
Molecular Function	GO:0016495	C-X3-C chemokine receptor activity	IDA	J:145036
Molecular Function	GO:0016495	C-X3-C chemokine receptor activity	IDA	J:263697
Molecular Function	GO:0004950	chemokine receptor activity	ISO	J:155856
Molecular Function	GO:0031737	CX3C chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0004896	cytokine receptor activity	IMP	J:145036
Molecular Function	GO:0004930	G protein-coupled receptor activity	IMP	J:263697
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:263697
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0097447	dendritic tree	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0032809	neuronal cell body membrane	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IMP	J:255660
Biological Process	GO:0061760	antifungal innate immune response	ISO	J:164563
Biological Process	GO:0061760	antifungal innate immune response	IMP	J:255660
Biological Process	GO:0035425	autocrine signaling	ISO	J:155856
Biological Process	GO:0007420	brain development	IMP	J:175794
Biological Process	GO:0007155	cell adhesion	IPI	J:263697
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0060326	cell chemotaxis	ISO	J:155856
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IGI	J:262355
Biological Process	GO:0021626	central nervous system maturation	IMP	J:211924
Biological Process	GO:0070098	chemokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0006935	chemotaxis	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0048874	host-mediated regulation of intestinal microbiota composition	IMP	J:255660
Biological Process	GO:0048874	host-mediated regulation of intestinal microbiota composition	IMP	J:95694
Biological Process	GO:0006955	immune response	IMP	J:95694
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IC	J:262355
Biological Process	GO:0030595	leukocyte chemotaxis	IMP	J:129712
Biological Process	GO:0050901	leukocyte tethering or rolling	IGI	J:263697
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:211924
Biological Process	GO:0150090	multiple spine synapse organization, single dendrite	IMP	J:211924
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:155856
Biological Process	GO:0002881	negative regulation of chronic inflammatory response to non-antigenic stimulus	ISO	J:155856
Biological Process	GO:0110091	negative regulation of hippocampal neuron apoptotic process	ISO	J:155856
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	ISO	J:155856
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:1904150	negative regulation of microglial cell mediated cytotoxicity	IMP	J:110266
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	J:263697
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:1903721	positive regulation of I-kappaB phosphorylation	ISO	J:155856
Biological Process	GO:1904141	positive regulation of microglial cell migration	ISO	J:155856
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	IMP	J:90912
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	ISO	J:155856
Biological Process	GO:0050769	positive regulation of neurogenesis	IMP	J:263388
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0045428	regulation of nitric oxide biosynthetic process	IGI	J:262355
Biological Process	GO:0032680	regulation of tumor necrosis factor production	IGI	J:262355
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0035176	social behavior	IMP	J:211924
Biological Process	GO:0060074	synapse maturation	IMP	J:211924
Biological Process	GO:0098883	synapse pruning	IMP	J:175794

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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