GO Annotations Graph

• Symbol: Itpka
• Name: inositol 1,4,5-trisphosphate 3-kinase A
• ID: MGI:1333822

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	ISO	J:155856
Molecular Function	GO:0051765	inositol tetrakisphosphate kinase activity	IBA	J:265628
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	ISO	J:164563
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	ISO	J:155856
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0031267	small GTPase binding	ISO	J:73065
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0043197	dendritic spine	ISO	J:73065
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton	ISO	J:155856
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:73065
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:0097062	dendritic spine maintenance	ISO	J:73065
Biological Process	GO:0006020	inositol metabolic process	IMP	J:51150
Biological Process	GO:0032958	inositol phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	ISO	J:155856
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:73065
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:154754
Biological Process	GO:0051592	response to calcium ion	ISO	J:164563