GO Annotations Graph

• Symbol: Pde3b
• Name: phosphodiesterase 3B, cGMP-inhibited
• ID: MGI:1333863

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IDA	J:135467
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:155856
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IBA	J:265628
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	ISO	J:155856
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:155856
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Molecular Function	GO:0043422	protein kinase B binding	IPI	J:135467
Molecular Function	GO:0043422	protein kinase B binding	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-162352
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:148079
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:148079
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:135467
Cellular Component	GO:0016020	membrane	IDA	J:148079
Cellular Component	GO:0016020	membrane	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0032869	cellular response to insulin stimulus	IEP	J:135467
Biological Process	GO:0031018	endocrine pancreas development	IDA	J:89497
Biological Process	GO:0042593	glucose homeostasis	IDA	J:89497
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	IBA	J:265628
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0050995	negative regulation of lipid catabolic process	ISO	J:164563
Biological Process	GO:0045765	regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0050796	regulation of insulin secretion	IDA	J:89497
Biological Process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:72247