Pikfyve GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Pikfyve
phosphoinositide kinase, FYVE type zinc finger containing
MGI:1335106

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	ISO	J:164563
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	IDA	J:292524
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	IDA	J:292526
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	IDA	J:135218
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	TAS	Reactome:R-NUL-1675886
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	TAS	Reactome:R-NUL-1675925
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	TAS	Reactome:R-NUL-1675982
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	IBA	J:265628
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA	J:51612
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	ISO	J:164563
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	IDA	J:135218
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	IDA	J:292526
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	IDA	J:292524
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	TAS	Reactome:R-NUL-1676051
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IDA	J:292523
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0016307	phosphatidylinositol phosphate kinase activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:137431
Molecular Function	GO:0005515	protein binding	IPI	J:292523
Molecular Function	GO:0005515	protein binding	IPI	J:147603
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:292526
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	IDA	J:51612
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0031410	cytoplasmic vesicle	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:135217
Cellular Component	GO:0005829	cytosol	IDA	J:135217
Cellular Component	GO:0031901	early endosome membrane	ISO	J:164563
Cellular Component	GO:0031901	early endosome membrane	TAS	Reactome:R-NUL-1675886
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0000139	Golgi membrane	TAS	Reactome:R-NUL-1675982
Cellular Component	GO:0031902	late endosome membrane	TAS	Reactome:R-NUL-1675925
Cellular Component	GO:0031902	late endosome membrane	TAS	Reactome:R-NUL-1676051
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:147603
Cellular Component	GO:0030670	phagocytic vesicle membrane	ISO	J:164563
Cellular Component	GO:0012506	vesicle membrane	IDA	J:51612
Cellular Component	GO:0012506	vesicle membrane	IBA	J:265628
Biological Process	GO:1903100	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process	IDA	J:292526
Biological Process	GO:1903100	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process	IDA	J:292524
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:51612
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0032438	melanosome organization	IMP	J:262141
Biological Process	GO:0032438	melanosome organization	ISO	J:164563
Biological Process	GO:0032438	melanosome organization	IBA	J:265628
Biological Process	GO:0032288	myelin assembly	IGI	J:177998
Biological Process	GO:0030593	neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	IDA	J:251375
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	IDA	J:292526
Biological Process	GO:0090382	phagosome maturation	IDA	J:289081
Biological Process	GO:0090382	phagosome maturation	ISO	J:164563
Biological Process	GO:0090385	phagosome-lysosome fusion	ISO	J:164563
Biological Process	GO:0090385	phagosome-lysosome fusion	IDA	J:251375
Biological Process	GO:0090385	phagosome-lysosome fusion	IBA	J:265628
Biological Process	GO:1904562	phosphatidylinositol 5-phosphate metabolic process	IDA	J:292524
Biological Process	GO:1904562	phosphatidylinositol 5-phosphate metabolic process	IDA	J:292526
Biological Process	GO:0046488	phosphatidylinositol metabolic process	IEA	J:72247
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0034504	protein localization to nucleus	ISO	J:164563
Biological Process	GO:0006612	protein targeting to membrane	IDA	J:292523
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell	ISO	J:164563
Biological Process	GO:2000785	regulation of autophagosome assembly	ISO	J:164563
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	ISO	J:164563
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	IDA	J:251375
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	IBA	J:265628
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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