GO Annotations Graph

• Symbol: Cflar
• Name: CASP8 and FADD-like apoptosis regulator
• ID: MGI:1336166

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IEA	J:72247
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:72247
Molecular Function	GO:0005123	death receptor binding	ISO	J:155856
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0016504	peptidase activator activity	IDA	J:170814
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:279494
Molecular Function	GO:0005515	protein binding	IPI	J:170814
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:104561
Cellular Component	GO:0031264	death-inducing signaling complex	ISO	J:155856
Cellular Component	GO:0031264	death-inducing signaling complex	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0097342	ripoptosome	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	IMP	J:104561
Biological Process	GO:0006915	apoptotic process	IMP	J:104561
Biological Process	GO:0071732	cellular response to nitric oxide	ISO	J:155856
Biological Process	GO:0030218	erythrocyte differentiation	IBA	J:265628
Biological Process	GO:0030216	keratinocyte differentiation	IBA	J:265628
Biological Process	GO:0070266	necroptotic process	IGI	J:170814
Biological Process	GO:0070266	necroptotic process	IGI	J:170814
Biological Process	GO:0070266	necroptotic process	IGI	J:170814
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:104561
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:1903845	negative regulation of cellular response to transforming growth factor beta stimulus	ISO	J:155856
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:104561
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	ISO	J:155856
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IGI	J:196028
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IGI	J:196028
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:230059
Biological Process	GO:1903944	negative regulation of hepatocyte apoptotic process	ISO	J:155856
Biological Process	GO:1901740	negative regulation of myoblast fusion	IMP	J:228559
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:170814
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:170814
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:196028
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:202809
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:170814
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	ISO	J:155856
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0043065	positive regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:1903055	positive regulation of extracellular matrix organization	ISO	J:155856
Biological Process	GO:0072126	positive regulation of glomerular mesangial cell proliferation	ISO	J:155856
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:228559
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0060544	regulation of necroptotic process	ISO	J:164563
Biological Process	GO:0014842	regulation of skeletal muscle satellite cell proliferation	IMP	J:228559
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0033574	response to testosterone	ISO	J:155856
Biological Process	GO:0014732	skeletal muscle atrophy	IMP	J:228559
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:228559
Biological Process	GO:0043403	skeletal muscle tissue regeneration	IMP	J:228559
Biological Process	GO:0014866	skeletal myofibril assembly	IMP	J:228559
Biological Process	GO:0042060	wound healing	IMP	J:228559