GO Annotations Graph

• Symbol: Cradd
• Name: CASP2 and RIPK1 domain containing adaptor with death domain
• ID: MGI:1336168

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070513	death domain binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	IBA	J:265628
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:184735
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:1905369	endopeptidase complex	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	NAS	J:246097
Cellular Component	GO:0005634	nucleus	IDA	J:184735
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA	J:265628
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IGI	J:101402
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0071260	cellular response to mechanical stimulus	IBA	J:265628
Biological Process	GO:0006974	DNA damage response	NAS	J:320335
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO	J:164563
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IBA	J:265628
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	NAS	J:320335
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IGI	J:101402
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0007165	signal transduction	IEA	J:72247