GO Annotations Graph

• Symbol: Tpp1
• Name: tripeptidyl peptidase I
• ID: MGI:1336194

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	ISS	J:116240
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:155856
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0035727	lysophosphatidic acid binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	ISS	J:116240
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0042277	peptide binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:235261
Molecular Function	GO:0005515	protein binding	IPI	J:115639
Molecular Function	GO:0004252	serine-type endopeptidase activity	IEA	J:72247
Molecular Function	GO:0008236	serine-type peptidase activity	ISO	J:164563
Molecular Function	GO:0008236	serine-type peptidase activity	ISS	J:116240
Molecular Function	GO:0120146	sulfatide binding	ISO	J:164563
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	ISS	J:116240
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	ISO	J:155856
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	ISO	J:164563
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	IBA	J:265628
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	IDA	J:250046
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IDA	J:235261
Cellular Component	GO:0005764	lysosome	ISS	J:116240
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Biological Process	GO:0045453	bone resorption	ISS	J:116240
Biological Process	GO:0045453	bone resorption	ISO	J:164563
Biological Process	GO:0007417	central nervous system development	IBA	J:265628
Biological Process	GO:1905146	lysosomal protein catabolic process	IMP	J:250046
Biological Process	GO:0007040	lysosome organization	IMP	J:94884
Biological Process	GO:0007040	lysosome organization	IMP	J:94884
Biological Process	GO:0007040	lysosome organization	IMP	J:94884
Biological Process	GO:0007040	lysosome organization	IMP	J:94884
Biological Process	GO:0007040	lysosome organization	IMP	J:94884
Biological Process	GO:0007040	lysosome organization	IMP	J:94884
Biological Process	GO:0007040	lysosome organization	IMP	J:94884
Biological Process	GO:0007040	lysosome organization	IMP	J:94884
Biological Process	GO:0007399	nervous system development	ISS	J:116240
Biological Process	GO:0007399	nervous system development	ISO	J:164563
Biological Process	GO:0050885	neuromuscular process controlling balance	IMP	J:94884
Biological Process	GO:0043171	peptide catabolic process	ISO	J:164563
Biological Process	GO:0043171	peptide catabolic process	ISS	J:116240
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0070198	protein localization to chromosome, telomeric region	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISS	J:116240
Biological Process	GO:0006508	proteolysis	IBA	J:265628