GO Annotations Graph

• Symbol: Fkbp1b
• Name: FK506 binding protein 1b
• ID: MGI:1336205

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019855	calcium channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0030551	cyclic nucleotide binding	ISO	J:155856
Molecular Function	GO:0005528	FK506 binding	ISO	J:155856
Molecular Function	GO:0005528	FK506 binding	ISO	J:164563
Molecular Function	GO:0005528	FK506 binding	IDA	J:87932
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	ISO	J:164563
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	ISO	J:164563
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IDA	J:107249
Molecular Function	GO:0005515	protein binding	IPI	J:187976
Molecular Function	GO:0005515	protein binding	IPI	J:87932
Molecular Function	GO:0005515	protein binding	IPI	J:107249
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:156537
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:115187
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:176005
Cellular Component	GO:0034704	calcium channel complex	IDA	J:115187
Cellular Component	GO:0034704	calcium channel complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:172481
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:176005
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:107249
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:87932
Cellular Component	GO:0030018	Z disc	ISO	J:164563
Biological Process	GO:0030073	insulin secretion	IMP	J:136192
Biological Process	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	IMP	J:156630
Biological Process	GO:0010459	negative regulation of heart rate	IMP	J:107733
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:156630
Biological Process	GO:0032515	negative regulation of phosphoprotein phosphatase activity	ISO	J:164563
Biological Process	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	ISO	J:164563
Biological Process	GO:0019227	neuronal action potential propagation	IMP	J:86699
Biological Process	GO:0048680	positive regulation of axon regeneration	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IMP	J:156630
Biological Process	GO:0051284	positive regulation of sequestering of calcium ion	ISO	J:164563
Biological Process	GO:0000413	protein peptidyl-prolyl isomerization	ISO	J:164563
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IMP	J:107733
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IBA	J:265628
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	IMP	J:198903
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0002027	regulation of heart rate	IMP	J:110224
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO	J:164563
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP	J:172481
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP	J:87932
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP	J:110224
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	IMP	J:107733
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:105461
Biological Process	GO:0009749	response to glucose	IMP	J:136192
Biological Process	GO:0051775	response to redox state	ISO	J:164563
Biological Process	GO:0006939	smooth muscle contraction	IMP	J:87932
Biological Process	GO:0042098	T cell proliferation	IMP	J:86699