GO Annotations Graph

• Symbol: Smad6
• Name: SMAD family member 6
• ID: MGI:1336883

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0070410	co-SMAD binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:201257
Molecular Function	GO:0005515	protein binding	IPI	J:200447
Molecular Function	GO:0005515	protein binding	IPI	J:109361
Molecular Function	GO:0070412	R-SMAD binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0140416	transcription regulator inhibitor activity	ISO	J:164563
Molecular Function	GO:0140416	transcription regulator inhibitor activity	IBA	J:265628
Molecular Function	GO:0070698	type I activin receptor binding	ISO	J:164563
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	IBA	J:265628
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:198828
Cellular Component	GO:0005667	transcription regulator complex	IEA	J:72247
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0035904	aorta development	IMP	J:222159
Biological Process	GO:0003180	aortic valve morphogenesis	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0060948	cardiac vascular smooth muscle cell development	TAS	J:169941
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0031589	cell-substrate adhesion	ISO	J:164563
Biological Process	GO:0060976	coronary vasculature development	IMP	J:222159
Biological Process	GO:0060977	coronary vasculature morphogenesis	TAS	J:169941
Biological Process	GO:0045444	fat cell differentiation	ISO	J:164563
Biological Process	GO:0003170	heart valve development	IMP	J:222159
Biological Process	GO:0006955	immune response	ISO	J:164563
Biological Process	GO:0003183	mitral valve morphogenesis	IMP	J:60214
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0030279	negative regulation of ossification	IMP	J:60214
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0010991	negative regulation of SMAD protein complex assembly	ISO	J:164563
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0003148	outflow tract septum morphogenesis	IMP	J:60214
Biological Process	GO:1902895	positive regulation of miRNA transcription	IMP	J:169047
Biological Process	GO:0045907	positive regulation of vasoconstriction	TAS	J:169941
Biological Process	GO:0003184	pulmonary valve morphogenesis	IMP	J:60214
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0001657	ureteric bud development	IEP	J:95433
Biological Process	GO:0042310	vasoconstriction	TAS	J:169941
Biological Process	GO:0003281	ventricular septum development	IMP	J:222159
Biological Process	GO:0007352	zygotic specification of dorsal/ventral axis	ISO	J:164563