GO Annotations Graph

• Symbol: Trp73
• Name: transformation related protein 73
• ID: MGI:1336991

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:104687
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:105215
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:104726
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:200512
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:224739
Cellular Component	GO:0005634	nucleus	IDA	J:96577
Cellular Component	GO:0005634	nucleus	IDA	J:86247
Cellular Component	GO:0005634	nucleus	IDA	J:97170
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:72247
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0033326	cerebrospinal fluid secretion	IMP	J:60896
Biological Process	GO:0048546	digestive tract morphogenesis	IMP	J:60896
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IMP	J:104726
Biological Process	GO:0030900	forebrain development	IMP	J:96577
Biological Process	GO:0021766	hippocampus development	IMP	J:60896
Biological Process	GO:0006954	inflammatory response	IMP	J:60896
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO	J:164563
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI	J:99862
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI	J:99862
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	ISO	J:139804
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:109212
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:63419
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:97170
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IDA	J:109212
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0048666	neuron development	IMP	J:109212
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IGI	J:104726
Biological Process	GO:0045793	positive regulation of cell size	IMP	J:97170
Biological Process	GO:0045793	positive regulation of cell size	IMP	J:109212
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:105215
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:104726
Biological Process	GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI	J:99862
Biological Process	GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI	J:99862
Biological Process	GO:1901248	positive regulation of lung ciliated cell differentiation	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0009791	post-embryonic development	IMP	J:60896
Biological Process	GO:0009791	post-embryonic development	IMP	J:97170
Biological Process	GO:0051262	protein tetramerization	IEA	J:72247
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	ISO	J:139804
Biological Process	GO:0007346	regulation of mitotic cell cycle	ISO	J:139804
Biological Process	GO:0043523	regulation of neuron apoptotic process	IGI	J:97170
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628