GO Annotations Graph

• Symbol: Mapk11
• Name: mitogen-activated protein kinase 11
• ID: MGI:1338024

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004707	MAP kinase activity	ISO	J:164563
Molecular Function	GO:0004707	MAP kinase activity	ISS	J:113819
Molecular Function	GO:0004707	MAP kinase activity	ISO	J:155856
Molecular Function	GO:0004707	MAP kinase activity	IMP	J:163789
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	EXP	J:168204
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-1605464
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-448953
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-448960
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-448961
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-451204
Cellular Component	GO:0005829	cytosol	IMP	J:163789
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-1605464
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0060348	bone development	IMP	J:163789
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:176023
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:164563
Biological Process	GO:0071493	cellular response to UV-B	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0000165	MAPK cascade	IMP	J:163789
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	IMP	J:176023
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:163789
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0060043	regulation of cardiac muscle cell proliferation	IGI	J:176023
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0051403	stress-activated MAPK cascade	ISS	J:113819
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	ISO	J:164563