GO Annotations Graph

• Symbol: Spint2
• Name: serine protease inhibitor, Kunitz type 2
• ID: MGI:1338031

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030414	peptidase inhibitor activity	IEA	J:60000
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0071711	basement membrane organization	IMP	J:152846
Biological Process	GO:0060672	epithelial cell morphogenesis involved in placental branching	IGI	J:152846
Biological Process	GO:0060672	epithelial cell morphogenesis involved in placental branching	IMP	J:152846
Biological Process	GO:0007163	establishment or maintenance of cell polarity	IMP	J:152846
Biological Process	GO:2000146	negative regulation of cell motility	ISO	J:73065
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	ISO	J:73065
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	ISO	J:155856
Biological Process	GO:0010466	negative regulation of peptidase activity	IEA	J:60000
Biological Process	GO:0001843	neural tube closure	IGI	J:152846
Biological Process	GO:0001843	neural tube closure	IMP	J:152846
Biological Process	GO:0001843	neural tube closure	IGI	J:152846