GO Annotations Graph

• Symbol: Itgb8
• Name: integrin beta 8
• ID: MGI:1338035

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1990430	extracellular matrix protein binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0034686	integrin alphav-beta8 complex	IDA	J:197004
Cellular Component	GO:0034686	integrin alphav-beta8 complex	ISO	J:164563
Cellular Component	GO:0008305	integrin complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0051216	cartilage development	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0033627	cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0007160	cell-matrix adhesion	NAS	J:319996
Biological Process	GO:0001573	ganglioside metabolic process	IMP	J:102190
Biological Process	GO:0060022	hard palate development	IGI	J:145991
Biological Process	GO:0006955	immune response	IGI	J:145991
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0061520	Langerhans cell differentiation	IGI	J:145991
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:1901388	regulation of transforming growth factor beta activation	IDA	J:197004
Biological Process	GO:1901388	regulation of transforming growth factor beta activation	ISO	J:164563
Biological Process	GO:0009615	response to virus	IGI	J:281014
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IGI	J:281014
Biological Process	GO:0001570	vasculogenesis	ISO	J:164563