GO Annotations Graph

• Symbol: Ikbkb
• Name: inhibitor of kappaB kinase beta
• ID: MGI:1338071

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008384	IkappaB kinase activity	ISO	J:155856
Molecular Function	GO:0008384	IkappaB kinase activity	IDA	J:146016
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:106690
Molecular Function	GO:0005515	protein binding	IPI	J:216669
Molecular Function	GO:0005515	protein binding	IPI	J:206842
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:166021
Molecular Function	GO:0005515	protein binding	IPI	J:228302
Molecular Function	GO:0005515	protein binding	IPI	J:187567
Molecular Function	GO:0005515	protein binding	IPI	J:160329
Molecular Function	GO:0005515	protein binding	IPI	J:160362
Molecular Function	GO:0005515	protein binding	IPI	J:248213
Molecular Function	GO:0005515	protein binding	IPI	J:182492
Molecular Function	GO:0005515	protein binding	IPI	J:160776
Molecular Function	GO:0005515	protein binding	IPI	J:163158
Molecular Function	GO:0005515	protein binding	IPI	J:116077
Molecular Function	GO:0005515	protein binding	IPI	J:181952
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IDA	J:98564
Molecular Function	GO:0004672	protein kinase activity	IMP	J:79132
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	IPI	J:126125
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:216669
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:205449
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:1990459	transferrin receptor binding	ISO	J:164563
Cellular Component	GO:0035631	CD40 receptor complex	IDA	J:161997
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	TAS	J:51176
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	IDA	J:161997
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0008385	IkappaB kinase complex	ISO	J:155856
Cellular Component	GO:0008385	IkappaB kinase complex	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Biological Process	GO:0001782	B cell homeostasis	IMP	J:79132
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0007252	I-kappaB phosphorylation	TAS	J:51176
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:1903347	negative regulation of bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	ISO	J:164563
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:216669
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:2001259	positive regulation of cation channel activity	IGI	J:146016
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:97353
Biological Process	GO:0010765	positive regulation of sodium ion transport	IGI	J:146016
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:275558
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0042325	regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0061847	response to cholecystokinin	ISO	J:155856
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IMP	J:225413
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IBA	J:265628