Aire GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Aire
autoimmune regulator
MGI:1338803

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0042393	histone binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	IPI	J:177171
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0045182	translation regulator activity	IEA	J:72247
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:68936
Cellular Component	GO:0005737	cytoplasm	IDA	J:68936
Cellular Component	GO:0005737	cytoplasm	IDA	J:68936
Cellular Component	GO:0001674	female germ cell nucleus	IDA	J:68936
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:124288
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:68936
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:68936
Cellular Component	GO:0016604	nuclear body	IDA	J:141379
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:77873
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:77873
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:77873
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:77873
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:77873
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Cellular Component	GO:0005634	nucleus	IDA	J:68936
Biological Process	GO:0002509	central tolerance induction to self antigen	ISO	J:164563
Biological Process	GO:0002509	central tolerance induction to self antigen	IBA	J:265628
Biological Process	GO:0006959	humoral immune response	IBA	J:265628
Biological Process	GO:0006959	humoral immune response	IMP	J:77873
Biological Process	GO:0045060	negative thymic T cell selection	IBA	J:265628
Biological Process	GO:0045060	negative thymic T cell selection	IGI	J:196474
Biological Process	GO:0002458	peripheral T cell tolerance induction	IDA	J:208220
Biological Process	GO:0002458	peripheral T cell tolerance induction	IBA	J:265628
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:157503
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:124288
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:124288
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:124288
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:124288
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:124288
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:124288
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:124288
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:124288
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2000410	regulation of thymocyte migration	IMP	J:157503
Biological Process	GO:2000410	regulation of thymocyte migration	IBA	J:265628
Biological Process	GO:0097536	thymus epithelium morphogenesis	IMP	J:141379
Biological Process	GO:0097536	thymus epithelium morphogenesis	IBA	J:265628
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:124288

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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