GO Annotations Graph

• Symbol: Dio2
• Name: deiodinase, iodothyronine, type II
• ID: MGI:1338833

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	ISO	J:155856
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	IDA	J:115535
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	ISO	J:164563
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	IBA	J:265628
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	IMP	J:72958
Molecular Function	GO:0033798	thyroxine 5-deiodinase activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:0050873	brown fat cell differentiation	IDA	J:245403
Biological Process	GO:0044255	cellular lipid metabolic process	IMP	J:270723
Biological Process	GO:0042446	hormone biosynthetic process	IEA	J:60000
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:77694
Biological Process	GO:0009409	response to cold	ISO	J:155856
Biological Process	GO:0042404	thyroid hormone catabolic process	IMP	J:72958
Biological Process	GO:0006590	thyroid hormone generation	ISO	J:155856
Biological Process	GO:0042403	thyroid hormone metabolic process	ISO	J:155856
Biological Process	GO:0042403	thyroid hormone metabolic process	ISO	J:164563
Biological Process	GO:0042403	thyroid hormone metabolic process	IBA	J:265628
Biological Process	GO:0070460	thyroid-stimulating hormone secretion	TAS	J:115535