GO Annotations Graph

• Symbol: Mthfd2
• Name: methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
• ID: MGI:1338850

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	ISO	J:164563
Molecular Function	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	IDA	J:9668
Molecular Function	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	IBA	J:265628
Molecular Function	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	ISO	J:164563
Molecular Function	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	IDA	J:9668
Molecular Function	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	IBA	J:265628
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	ISO	J:164563
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	IDA	J:9668
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	IBA	J:265628
Molecular Function	GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	IEA	J:72245
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0042301	phosphate ion binding	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0006730	one-carbon metabolic process	IEA	J:60000
Biological Process	GO:0035999	tetrahydrofolate interconversion	IBA	J:265628
Biological Process	GO:0046653	tetrahydrofolate metabolic process	ISO	J:164563