P2rx4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

P2rx4
purinergic receptor P2X, ligand-gated ion channel 4
MGI:1338859

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0045296	cadherin binding	ISO	J:164563
Molecular Function	GO:0005507	copper ion binding	ISO	J:155856
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	ISO	J:155856
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	IBA	J:265628
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	TAS	J:52365
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	IMP	J:97222
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0099604	ligand-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0099604	ligand-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	ISO	J:164563
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0045177	apical part of cell	IDA	J:122385
Cellular Component	GO:0045177	apical part of cell	IDA	J:122385
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISS	J:52365
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0048266	behavioral response to pain	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IMP	J:104459
Biological Process	GO:0071318	cellular response to ATP	ISO	J:155856
Biological Process	GO:0071318	cellular response to ATP	ISO	J:164563
Biological Process	GO:0071294	cellular response to zinc ion	ISO	J:155856
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:112177
Biological Process	GO:0098662	inorganic cation transmembrane transport	ISO	J:155856
Biological Process	GO:0051899	membrane depolarization	ISO	J:164563
Biological Process	GO:0098655	monoatomic cation transmembrane transport	IEA	J:72247
Biological Process	GO:0034220	monoatomic ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0010614	negative regulation of cardiac muscle hypertrophy	ISO	J:164563
Biological Process	GO:0019228	neuronal action potential	ISO	J:155856
Biological Process	GO:0006809	nitric oxide biosynthetic process	IDA	J:104459
Biological Process	GO:0006809	nitric oxide biosynthetic process	IMP	J:104459
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	ISO	J:164563
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	ISO	J:164563
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis	ISO	J:164563
Biological Process	GO:1904141	positive regulation of microglial cell migration	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0035590	purinergic nucleotide receptor signaling pathway	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:164563
Biological Process	GO:0055117	regulation of cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0050920	regulation of chemotaxis	ISO	J:155856
Biological Process	GO:0002028	regulation of sodium ion transport	ISO	J:155856
Biological Process	GO:0055119	relaxation of cardiac muscle	ISO	J:164563
Biological Process	GO:0033198	response to ATP	ISO	J:164563
Biological Process	GO:0048678	response to axon injury	ISO	J:155856
Biological Process	GO:0034405	response to fluid shear stress	ISO	J:164563
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0050975	sensory perception of touch	ISO	J:155856
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0042311	vasodilation	IMP	J:104459

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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