GO Annotations Graph

• Symbol: Uhrf1
• Name: ubiquitin-like, containing PHD and RING finger domains, 1
• ID: MGI:1338889

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0044729	hemi-methylated DNA-binding	ISO	J:164563
Molecular Function	GO:0044729	hemi-methylated DNA-binding	IDA	J:129097
Molecular Function	GO:0042393	histone binding	IDA	J:89061
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:89061
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008327	methyl-CpG binding	ISO	J:164563
Molecular Function	GO:0035064	methylated histone binding	ISO	J:164563
Molecular Function	GO:0035064	methylated histone binding	IDA	J:190276
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:129097
Molecular Function	GO:0005515	protein binding	IPI	J:188893
Molecular Function	GO:0005515	protein binding	IPI	J:243489
Molecular Function	GO:0005515	protein binding	IPI	J:140323
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:89061
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:89061
Cellular Component	GO:0000785	chromatin	IDA	J:129097
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0000791	euchromatin	ISO	J:164563
Cellular Component	GO:0000792	heterochromatin	ISO	J:164563
Cellular Component	GO:0000792	heterochromatin	IDA	J:190276
Cellular Component	GO:0000792	heterochromatin	IDA	J:129097
Cellular Component	GO:0000792	heterochromatin	IDA	J:140323
Cellular Component	GO:0016363	nuclear matrix	IDA	J:89061
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5336231
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5336365
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5336369
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	TAS	J:52005
Cellular Component	GO:0005634	nucleus	IDA	J:129097
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005657	replication fork	ISO	J:164563
Cellular Component	GO:0005657	replication fork	IDA	J:129097
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0010390	histone monoubiquitination	IDA	J:89061
Biological Process	GO:0010390	histone monoubiquitination	IBA	J:265628
Biological Process	GO:0016574	histone ubiquitination	ISO	J:164563
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	IMP	J:129097
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	ISO	J:164563
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	IMP	J:188898
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:190276
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0051865	protein autoubiquitination	IDA	J:89061
Biological Process	GO:0050678	regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563