GO Annotations Graph

• Symbol: Acvrl1
• Name: activin A receptor, type II-like 1
• ID: MGI:1338946

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	ISO	J:164563
Molecular Function	GO:0016361	activin receptor activity, type I	ISO	J:73065
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0098821	BMP receptor activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:164086
Molecular Function	GO:0005515	protein binding	IPI	J:86237
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	ISO	J:73065
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	ISO	J:164563
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	IBA	J:265628
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72247
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72245
Cellular Component	GO:0070724	BMP receptor complex	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:73065
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IMP	J:65521
Biological Process	GO:0001525	angiogenesis	IMP	J:61177
Biological Process	GO:0060840	artery development	IMP	J:157791
Biological Process	GO:0008015	blood circulation	ISO	J:164563
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:122868
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:130020
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:157791
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:186473
Biological Process	GO:0071773	cellular response to BMP stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IDA	J:149284
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:164563
Biological Process	GO:0035912	dorsal aorta morphogenesis	IMP	J:85366
Biological Process	GO:0009953	dorsal/ventral pattern formation	IBA	J:265628
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:85366
Biological Process	GO:0042118	endothelial cell activation	TAS	J:164086
Biological Process	GO:0061154	endothelial tube morphogenesis	ISO	J:164563
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0001701	in utero embryonic development	IMP	J:130020
Biological Process	GO:0001946	lymphangiogenesis	IMP	J:157791
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	ISO	J:164563
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	IMP	J:157791
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	ISO	J:164563
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	IDA	J:164086
Biological Process	GO:0010596	negative regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	IDA	J:164086
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:85366
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045766	positive regulation of angiogenesis	IGI	J:204744
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IDA	J:164086
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:164086
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation	IDA	J:164086
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	IDA	J:164086
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:85366
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IMP	J:157791
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:86237
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA	J:72247
Biological Process	GO:0060841	venous blood vessel development	IMP	J:157791
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	ISO	J:164563