GO Annotations Graph

• Symbol: Pak3
• Name: p21 (RAC1) activated kinase 3
• ID: MGI:1339656

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0051020	GTPase binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004708	MAP kinase kinase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:30018
Molecular Function	GO:0005515	protein binding	IPI	J:201289
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	IDA	J:194236
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-442844
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0017124	SH3 domain binding	IEA	J:60000
Molecular Function	GO:0031267	small GTPase binding	IPI	J:148081
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-442844
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:239194
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:239194
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:90763
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:90763
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:90763
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:90763
Cellular Component	GO:0014069	postsynaptic density	IDA	J:90763
Cellular Component	GO:0014069	postsynaptic density	IDA	J:90763
Cellular Component	GO:0014069	postsynaptic density	IEP	J:90763
Cellular Component	GO:0014069	postsynaptic density	IDA	J:90763
Biological Process	GO:0007409	axonogenesis	IMP	J:169422
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:194236
Biological Process	GO:0016358	dendrite development	IMP	J:169422
Biological Process	GO:0060996	dendritic spine development	IGI	J:194236
Biological Process	GO:0060997	dendritic spine morphogenesis	IMP	J:239194
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:155856
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0030833	regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0050770	regulation of axonogenesis	IBA	J:265628
Biological Process	GO:0043408	regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0010975	regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:239194
Biological Process	GO:0099175	regulation of postsynapse organization	IMP	J:239194