GO Annotations Graph

• Symbol: Csf2
• Name: colony stimulating factor 2 (granulocyte-macrophage)
• ID: MGI:1339752

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:155856
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:1049
Molecular Function	GO:0005125	cytokine activity	IDA	J:98325
Molecular Function	GO:0005129	granulocyte macrophage colony-stimulating factor receptor binding	IEA	J:72247
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:15406
Cellular Component	GO:0005615	extracellular space	IDA	J:168000
Cellular Component	GO:0030526	granulocyte macrophage colony-stimulating factor receptor complex	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IDA	J:1049
Biological Process	GO:0008283	cell population proliferation	IDA	J:98325
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO	J:164563
Biological Process	GO:0097028	dendritic cell differentiation	ISO	J:155856
Biological Process	GO:0097028	dendritic cell differentiation	ISO	J:164563
Biological Process	GO:0001892	embryonic placenta development	IMP	J:152946
Biological Process	GO:0042045	epithelial fluid transport	ISO	J:155856
Biological Process	GO:0038157	granulocyte-macrophage colony-stimulating factor signaling pathway	ISO	J:164563
Biological Process	GO:0001821	histamine secretion	ISO	J:155856
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0042116	macrophage activation	ISO	J:155856
Biological Process	GO:0030225	macrophage differentiation	ISO	J:164563
Biological Process	GO:0030224	monocyte differentiation	IDA	J:147898
Biological Process	GO:0030099	myeloid cell differentiation	IBA	J:265628
Biological Process	GO:0043011	myeloid dendritic cell differentiation	ISO	J:164563
Biological Process	GO:0043011	myeloid dendritic cell differentiation	IDA	J:76770
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:0030223	neutrophil differentiation	IDA	J:147898
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:1049
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:98325
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0032747	positive regulation of interleukin-23 production	ISO	J:164563
Biological Process	GO:0070665	positive regulation of leukocyte proliferation	ISO	J:164563
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0071803	positive regulation of podosome assembly	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:60155
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IMP	J:152946
Biological Process	GO:0010468	regulation of gene expression	IDA	J:48838