GO Annotations Graph

• Symbol: Csf1r
• Name: colony stimulating factor 1 receptor
• ID: MGI:1339758

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0019955	cytokine binding	ISO	J:164563
Molecular Function	GO:0019955	cytokine binding	IDA	J:177179
Molecular Function	GO:0019955	cytokine binding	IPI	J:145880
Molecular Function	GO:0019838	growth factor binding	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0005011	macrophage colony-stimulating factor receptor activity	ISO	J:164563
Molecular Function	GO:0005011	macrophage colony-stimulating factor receptor activity	IMP	J:177179
Molecular Function	GO:0005011	macrophage colony-stimulating factor receptor activity	IDA	J:144524
Molecular Function	GO:0005011	macrophage colony-stimulating factor receptor activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:245355
Molecular Function	GO:0005515	protein binding	IPI	J:188483
Molecular Function	GO:0005515	protein binding	IPI	J:144524
Molecular Function	GO:0005515	protein binding	IPI	J:145880
Molecular Function	GO:0005515	protein binding	IPI	J:82584
Molecular Function	GO:0005515	protein binding	IPI	J:58748
Molecular Function	GO:0005515	protein binding	IPI	J:7888
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:145880
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019903	protein phosphatase binding	IPI	J:109622
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-9680706
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-9763901
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:7888
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:269764
Cellular Component	GO:0009986	cell surface	IDA	J:177179
Cellular Component	GO:1990682	CSF1-CSF1R complex	IDA	J:145880
Cellular Component	GO:1990682	CSF1-CSF1R complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:7888
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9680703
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9680705
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9680706
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9682572
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9763891
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9763892
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9763901
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9763903
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9764150
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9817994
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9818009
Cellular Component	GO:0005886	plasma membrane	IDA	J:98043
Cellular Component	GO:0005886	plasma membrane	IDA	J:193006
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0007411	axon guidance	IMP	J:185808
Biological Process	GO:0008283	cell population proliferation	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	ISO	J:155856
Biological Process	GO:0045217	cell-cell junction maintenance	ISO	J:164563
Biological Process	GO:0071345	cellular response to cytokine stimulus	IMP	J:164923
Biological Process	GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	IMP	J:177179
Biological Process	GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0021542	dentate gyrus development	ISO	J:155856
Biological Process	GO:0021879	forebrain neuron differentiation	IMP	J:185808
Biological Process	GO:0030097	hemopoiesis	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0038145	macrophage colony-stimulating factor signaling pathway	IDA	J:145880
Biological Process	GO:0038145	macrophage colony-stimulating factor signaling pathway	IDA	J:144524
Biological Process	GO:0014005	microglia development	ISO	J:155856
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0061518	microglial cell proliferation	IGI	J:269538
Biological Process	GO:0061518	microglial cell proliferation	ISO	J:155856
Biological Process	GO:0035702	monocyte homeostasis	ISO	J:155856
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:185808
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:185808
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	ISO	J:155856
Biological Process	GO:0010832	negative regulation of myotube differentiation	ISO	J:155856
Biological Process	GO:1905220	negative regulation of platelet formation	ISO	J:155856
Biological Process	GO:1990138	neuron projection extension	ISO	J:155856
Biological Process	GO:0001780	neutrophil homeostasis	ISO	J:155856
Biological Process	GO:0021772	olfactory bulb development	IMP	J:185808
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:164923
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:177158
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:177253
Biological Process	GO:0030316	osteoclast differentiation	IBA	J:265628
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:177179
Biological Process	GO:0046488	phosphatidylinositol metabolic process	IMP	J:177226
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IMP	J:177226
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0044794	positive regulation by host of viral process	IGI	J:166251
Biological Process	GO:0061890	positive regulation of astrocyte activation	ISO	J:155856
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:155856
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	IMP	J:177226
Biological Process	GO:2000147	positive regulation of cell motility	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:177179
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:177179
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0070665	positive regulation of leukocyte proliferation	ISO	J:155856
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	ISO	J:155856
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	ISO	J:164563
Biological Process	GO:1905523	positive regulation of macrophage migration	ISO	J:155856
Biological Process	GO:0120041	positive regulation of macrophage proliferation	ISO	J:155856
Biological Process	GO:0120041	positive regulation of macrophage proliferation	ISO	J:164563
Biological Process	GO:2000288	positive regulation of myoblast proliferation	ISO	J:155856
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	IMP	J:177226
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP	J:177179
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:177179
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:164923
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	IMP	J:177226
Biological Process	GO:0045124	regulation of bone resorption	ISO	J:155856
Biological Process	GO:0008360	regulation of cell shape	IMP	J:177226
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	ISO	J:155856
Biological Process	GO:0043408	regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0032944	regulation of mononuclear cell proliferation	ISO	J:155856
Biological Process	GO:0002931	response to ischemia	IDA	J:269764
Biological Process	GO:0031529	ruffle organization	IMP	J:177226
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IDA	J:144524
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IMP	J:177180
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628