GO Annotations Graph

• Symbol: Smc3
• Name: structural maintenance of chromosomes 3
• ID: MGI:1339795

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016887	ATP hydrolysis activity	IEA	J:72247
Molecular Function	GO:0048487	beta-tubulin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:164442
Molecular Function	GO:0003682	chromatin binding	IDA	J:184719
Molecular Function	GO:0003682	chromatin binding	IDA	J:164442
Molecular Function	GO:0061775	cohesin loader activity	IBA	J:265628
Molecular Function	GO:0003690	double-stranded DNA binding	IBA	J:265628
Molecular Function	GO:0070840	dynein complex binding	ISO	J:164563
Molecular Function	GO:0036033	mediator complex binding	IDA	J:164442
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:56371
Molecular Function	GO:0005515	protein binding	IPI	J:158584
Molecular Function	GO:0005515	protein binding	IPI	J:84400
Molecular Function	GO:0005515	protein binding	IPI	J:84400
Molecular Function	GO:0005515	protein binding	IPI	J:84400
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Cellular Component	GO:0005604	basement membrane	ISO	J:155856
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:72247
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000775	chromosome, centromeric region	IEA	J:60000
Cellular Component	GO:0008278	cohesin complex	IDA	J:56371
Cellular Component	GO:0008278	cohesin complex	ISO	J:164563
Cellular Component	GO:0000800	lateral element	IDA	J:98372
Cellular Component	GO:0000800	lateral element	IDA	J:185266
Cellular Component	GO:0000800	lateral element	IDA	J:294078
Cellular Component	GO:0030893	meiotic cohesin complex	IDA	J:173689
Cellular Component	GO:0030893	meiotic cohesin complex	ISO	J:164563
Cellular Component	GO:0030893	meiotic cohesin complex	IDA	J:176168
Cellular Component	GO:0030893	meiotic cohesin complex	IDA	J:182264
Cellular Component	GO:0097431	mitotic spindle pole	ISO	J:164563
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912355
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912362
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912423
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912449
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912468
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912506
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:56371
Cellular Component	GO:0005634	nucleus	IDA	J:84400
Cellular Component	GO:0000795	synaptonemal complex	ISO	J:155856
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0051276	chromosome organization	IEA	J:72247
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0051321	meiotic cell cycle	ISO	J:164563
Biological Process	GO:0051321	meiotic cell cycle	IPI	J:84400
Biological Process	GO:0007064	mitotic sister chromatid cohesion	IBA	J:265628
Biological Process	GO:0090307	mitotic spindle assembly	ISO	J:164563
Biological Process	GO:0006275	regulation of DNA replication	ISO	J:164563
Biological Process	GO:0007062	sister chromatid cohesion	ISO	J:164563
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:164442