GO Annotations Graph

• Symbol: P2rx7
• Name: purinergic receptor P2X, ligand-gated ion channel, 7
• ID: MGI:1339957

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IMP	J:84145
Molecular Function	GO:0015267	channel activity	ISO	J:137037
Molecular Function	GO:0015267	channel activity	IMP	J:137037
Molecular Function	GO:0005507	copper ion binding	ISO	J:155856
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	ISO	J:155856
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	IBA	J:265628
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	IMP	J:84145
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	IMP	J:96213
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IPI	J:96213
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:70817
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:155856
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:92523
Molecular Function	GO:0005515	protein binding	IPI	J:92523
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:155856
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	ISO	J:164563
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	IMP	J:84145
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0032059	bleb	ISO	J:155856
Cellular Component	GO:0005911	cell-cell junction	IDA	J:92523
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:118682
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:96213
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	IPI	J:96213
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:96213
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:99778
Cellular Component	GO:0043025	neuronal cell body	IDA	J:103892
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IMP	J:84145
Cellular Component	GO:0005886	plasma membrane	IDA	J:92523
Cellular Component	GO:0005886	plasma membrane	ISS	J:51040
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:130842
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:1904669	ATP export	ISO	J:155856
Biological Process	GO:0032060	bleb assembly	ISO	J:155856
Biological Process	GO:0032060	bleb assembly	IMP	J:220493
Biological Process	GO:0032060	bleb assembly	ISO	J:164563
Biological Process	GO:0032060	bleb assembly	IMP	J:120291
Biological Process	GO:0006816	calcium ion transport	IMP	J:79540
Biological Process	GO:0000902	cell morphogenesis	IMP	J:111397
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:155856
Biological Process	GO:0006884	cell volume homeostasis	IDA	J:130933
Biological Process	GO:0071359	cellular response to dsRNA	IMP	J:214872
Biological Process	GO:0031668	cellular response to extracellular stimulus	IMP	J:130842
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:194901
Biological Process	GO:0046513	ceramide biosynthetic process	IDA	J:110330
Biological Process	GO:0032963	collagen metabolic process	IMP	J:136485
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:118561
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:105908
Biological Process	GO:0051649	establishment of localization in cell	IDA	J:91940
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:79540
Biological Process	GO:0051649	establishment of localization in cell	IDA	J:130933
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:105908
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:125172
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:118682
Biological Process	GO:0014051	gamma-aminobutyric acid secretion	IMP	J:103703
Biological Process	GO:0010467	gene expression	IMP	J:137037
Biological Process	GO:0014047	glutamate secretion	IMP	J:103703
Biological Process	GO:0014047	glutamate secretion	IMP	J:118643
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IMP	J:136485
Biological Process	GO:0006954	inflammatory response	IMP	J:136485
Biological Process	GO:0006954	inflammatory response	IMP	J:111397
Biological Process	GO:0032610	interleukin-1 alpha production	IMP	J:136350
Biological Process	GO:0032611	interleukin-1 beta production	IMP	J:136350
Biological Process	GO:0032611	interleukin-1 beta production	IMP	J:66835
Biological Process	GO:0032611	interleukin-1 beta production	IMP	J:99000
Biological Process	GO:0032635	interleukin-6 production	IMP	J:66835
Biological Process	GO:0070227	lymphocyte apoptotic process	IMP	J:129413
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:66835
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:136350
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:136350
Biological Process	GO:0000165	MAPK cascade	IMP	J:100823
Biological Process	GO:0051899	membrane depolarization	ISO	J:155856
Biological Process	GO:0051899	membrane depolarization	ISO	J:164563
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IMP	J:118682
Biological Process	GO:0051882	mitochondrial depolarization	IMP	J:102387
Biological Process	GO:0007005	mitochondrion organization	IDA	J:110330
Biological Process	GO:0098655	monoatomic cation transmembrane transport	IEA	J:72247
Biological Process	GO:0006812	monoatomic cation transport	IMP	J:84145
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0043132	NAD transport	IMP	J:125172
Biological Process	GO:0045779	negative regulation of bone resorption	IMP	J:84145
Biological Process	GO:0045794	negative regulation of cell volume	IMP	J:220493
Biological Process	GO:0045794	negative regulation of cell volume	ISO	J:164563
Biological Process	GO:0043409	negative regulation of MAPK cascade	IDA	J:70817
Biological Process	GO:0019228	neuronal action potential	ISO	J:155856
Biological Process	GO:0001845	phagolysosome assembly	IMP	J:118561
Biological Process	GO:0006649	phospholipid transfer to membrane	IMP	J:79540
Biological Process	GO:0045332	phospholipid translocation	IDA	J:130933
Biological Process	GO:0007009	plasma membrane organization	IDA	J:130933
Biological Process	GO:0017121	plasma membrane phospholipid scrambling	ISO	J:164563
Biological Process	GO:0046931	pore complex assembly	ISO	J:155856
Biological Process	GO:0046931	pore complex assembly	ISO	J:164563
Biological Process	GO:0046931	pore complex assembly	IMP	J:79540
Biological Process	GO:0046931	pore complex assembly	IMP	J:105908
Biological Process	GO:0046931	pore complex assembly	IMP	J:100823
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:136485
Biological Process	GO:1904172	positive regulation of bleb assembly	ISO	J:164563
Biological Process	GO:0030501	positive regulation of bone mineralization	IMP	J:137037
Biological Process	GO:0030501	positive regulation of bone mineralization	IMP	J:84145
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	ISO	J:164563
Biological Process	GO:0043085	positive regulation of catalytic activity	IMP	J:89513
Biological Process	GO:0051495	positive regulation of cytoskeleton organization	ISO	J:155856
Biological Process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	IMP	J:103703
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0014049	positive regulation of glutamate secretion	IMP	J:103703
Biological Process	GO:0014049	positive regulation of glutamate secretion	IMP	J:118643
Biological Process	GO:0045821	positive regulation of glycolytic process	ISO	J:164563
Biological Process	GO:0032730	positive regulation of interleukin-1 alpha production	IMP	J:136350
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:155856
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:99000
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:136350
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:66835
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:66835
Biological Process	GO:0070230	positive regulation of lymphocyte apoptotic process	IMP	J:129413
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:136350
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:136350
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:136350
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:66835
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:66835
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IMP	J:118643
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:100823
Biological Process	GO:0051901	positive regulation of mitochondrial depolarization	IMP	J:102387
Biological Process	GO:0034767	positive regulation of monoatomic ion transmembrane transport	ISO	J:164563
Biological Process	GO:0045778	positive regulation of ossification	IMP	J:105908
Biological Process	GO:0045778	positive regulation of ossification	IMP	J:137037
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	IMP	J:105908
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	IMP	J:105908
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:121597
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:100823
Biological Process	GO:0050714	positive regulation of protein secretion	IDA	J:91940
Biological Process	GO:0070234	positive regulation of T cell apoptotic process	IMP	J:110330
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IMP	J:89513
Biological Process	GO:0012501	programmed cell death	IMP	J:89513
Biological Process	GO:0012501	programmed cell death	IMP	J:113208
Biological Process	GO:0012501	programmed cell death	IDA	J:113208
Biological Process	GO:0012501	programmed cell death	IDA	J:130933
Biological Process	GO:0012501	programmed cell death	IDA	J:130933
Biological Process	GO:0012501	programmed cell death	IMP	J:89513
Biological Process	GO:0032310	prostaglandin secretion	IMP	J:105908
Biological Process	GO:0032310	prostaglandin secretion	IMP	J:105908
Biological Process	GO:0030163	protein catabolic process	IDA	J:70817
Biological Process	GO:0006468	protein phosphorylation	IMP	J:118643
Biological Process	GO:0016485	protein processing	IMP	J:66835
Biological Process	GO:0009306	protein secretion	IDA	J:91940
Biological Process	GO:0035590	purinergic nucleotide receptor signaling pathway	ISO	J:164563
Biological Process	GO:0072593	reactive oxygen species metabolic process	IMP	J:121597
Biological Process	GO:0099161	regulation of presynaptic dense core granule exocytosis	ISO	J:155856
Biological Process	GO:0002028	regulation of sodium ion transport	ISO	J:155856
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:130842
Biological Process	GO:0033198	response to ATP	ISO	J:164563
Biological Process	GO:0033198	response to ATP	ISO	J:155856
Biological Process	GO:0033198	response to ATP	IMP	J:99778
Biological Process	GO:0033198	response to ATP	IMP	J:66835
Biological Process	GO:0033198	response to ATP	IDA	J:91940
Biological Process	GO:0033198	response to ATP	IMP	J:130842
Biological Process	GO:0033198	response to ATP	IDA	J:96213
Biological Process	GO:0033198	response to ATP	IMP	J:100823
Biological Process	GO:0033198	response to ATP	IMP	J:111397
Biological Process	GO:0033198	response to ATP	IMP	J:118682
Biological Process	GO:0033198	response to ATP	IMP	J:136350
Biological Process	GO:0033198	response to ATP	IMP	J:111397
Biological Process	GO:0033198	response to ATP	IMP	J:118561
Biological Process	GO:0033198	response to ATP	IMP	J:121597
Biological Process	GO:0033198	response to ATP	IMP	J:110330
Biological Process	GO:0033198	response to ATP	IMP	J:130933
Biological Process	GO:0033198	response to ATP	IMP	J:89513
Biological Process	GO:0033198	response to ATP	IMP	J:137037
Biological Process	GO:0033198	response to ATP	IMP	J:102387
Biological Process	GO:0033198	response to ATP	IMP	J:120291
Biological Process	GO:0033198	response to ATP	IMP	J:113208
Biological Process	GO:0009617	response to bacterium	IMP	J:97422
Biological Process	GO:0051592	response to calcium ion	IDA	J:91940
Biological Process	GO:0051592	response to calcium ion	IMP	J:130842
Biological Process	GO:0051592	response to calcium ion	IMP	J:99778
Biological Process	GO:0051602	response to electrical stimulus	IMP	J:103703
Biological Process	GO:0034405	response to fluid shear stress	IMP	J:105908
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:111397
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:121597
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:91940
Biological Process	GO:0009612	response to mechanical stimulus	IMP	J:105908
Biological Process	GO:0014070	response to organic cyclic compound	IDA	J:91940
Biological Process	GO:0010033	response to organic substance	IMP	J:129123
Biological Process	GO:0010033	response to organic substance	IMP	J:118682
Biological Process	GO:0010033	response to organic substance	IMP	J:113208
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:130842
Biological Process	GO:0010043	response to zinc ion	IMP	J:130842
Biological Process	GO:0010043	response to zinc ion	IMP	J:99778
Biological Process	GO:0019233	sensory perception of pain	IMP	J:101945
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:137037
Biological Process	GO:0016079	synaptic vesicle exocytosis	IMP	J:96213
Biological Process	GO:0070231	T cell apoptotic process	IMP	J:110330
Biological Process	GO:0043029	T cell homeostasis	IMP	J:113208
Biological Process	GO:0001913	T cell mediated cytotoxicity	IMP	J:89513
Biological Process	GO:0042098	T cell proliferation	IMP	J:118862
Biological Process	GO:0006900	vesicle budding from membrane	IMP	J:99000