GO Annotations Graph

• Symbol: Pak1
• Name: p21 (RAC1) activated kinase 1
• ID: MGI:1339975

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0005518	collagen binding	ISO	J:164563
Molecular Function	GO:0043015	gamma-tubulin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:140161
Molecular Function	GO:0005515	protein binding	IPI	J:65771
Molecular Function	GO:0005515	protein binding	IPI	J:200323
Molecular Function	GO:0005515	protein binding	IPI	J:188803
Molecular Function	GO:0005515	protein binding	IPI	J:161106
Molecular Function	GO:0005515	protein binding	IPI	J:182176
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IDA	J:86235
Molecular Function	GO:0004672	protein kinase activity	IDA	J:203580
Molecular Function	GO:0004672	protein kinase activity	IDA	J:194236
Molecular Function	GO:0004672	protein kinase activity	TAS	J:40334
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:243667
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISS	J:55429
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IDA	J:85489
Cellular Component	GO:0030424	axon	IDA	J:85489
Cellular Component	GO:0030424	axon	IDA	J:85489
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:79013
Cellular Component	GO:0005737	cytoplasm	IDA	J:85489
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:179583
Cellular Component	GO:0005925	focal adhesion	TAS	J:86235
Cellular Component	GO:0098982	GABA-ergic synapse	IEP	J:234293
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:234293
Cellular Component	GO:0098982	GABA-ergic synapse	IMP	J:234293
Cellular Component	GO:0098982	GABA-ergic synapse	EXP	J:234293
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:234293
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:234293
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:234293
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:90763
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:90763
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:90763
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:90763
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:90763
Cellular Component	GO:0030426	growth cone	IDA	J:73513
Cellular Component	GO:0014704	intercalated disc	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0031965	nuclear membrane	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:85489
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0014069	postsynaptic density	IDA	J:90763
Cellular Component	GO:0014069	postsynaptic density	IEP	J:90763
Cellular Component	GO:0014069	postsynaptic density	IDA	J:90763
Cellular Component	GO:0014069	postsynaptic density	IDA	J:90763
Cellular Component	GO:0014069	postsynaptic density	IDA	J:90763
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0001726	ruffle	ISO	J:164563
Cellular Component	GO:0001726	ruffle	ISO	J:155856
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:241798
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0021764	amygdala development	IGI	J:219424
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	ISO	J:164563
Biological Process	GO:0016477	cell migration	ISO	J:241798
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:194236
Biological Process	GO:0006338	chromatin remodeling	ISO	J:164563
Biological Process	GO:0016358	dendrite development	IDA	J:79013
Biological Process	GO:0060996	dendritic spine development	IGI	J:194236
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0030010	establishment of cell polarity	ISO	J:155856
Biological Process	GO:0006887	exocytosis	IEA	J:60000
Biological Process	GO:0061534	gamma-aminobutyric acid secretion, neurotransmission	IGI	J:219424
Biological Process	GO:0061535	glutamate secretion, neurotransmission	IGI	J:219424
Biological Process	GO:0048012	hepatocyte growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:0060244	negative regulation of cell proliferation involved in contact inhibition	ISO	J:164563
Biological Process	GO:0007528	neuromuscular junction development	IGI	J:78399
Biological Process	GO:0007528	neuromuscular junction development	IGI	J:78399
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0098597	observational learning	IGI	J:219424
Biological Process	GO:0016310	phosphorylation	ISO	J:164563
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:155856
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0090063	positive regulation of microtubule nucleation	ISO	J:164563
Biological Process	GO:0031116	positive regulation of microtubule polymerization	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	ISO	J:155856
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:1903608	protein localization to cytoplasmic stress granule	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0043113	receptor clustering	IGI	J:78399
Biological Process	GO:0043113	receptor clustering	IGI	J:78399
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0050770	regulation of axonogenesis	IBA	J:265628
Biological Process	GO:0010468	regulation of gene expression	IGI	J:219424
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	IGI	J:219424
Biological Process	GO:0043408	regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0043408	regulation of MAPK cascade	IGI	J:219424
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IMP	J:234293
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IEP	J:234293
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA	J:234293
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA	J:234293
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA	J:234293
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA	J:234293
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	EXP	J:234293
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0019226	transmission of nerve impulse	IGI	J:235660
Biological Process	GO:0042060	wound healing	ISO	J:164563