GO Annotations Graph

• Symbol: Lrp8
• Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
• ID: MGI:1340044

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	IPI	J:102174
Molecular Function	GO:0034185	apolipoprotein binding	IDA	J:180496
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0048306	calcium-dependent protein binding	IPI	J:180496
Molecular Function	GO:0008035	high-density lipoprotein particle binding	ISO	J:155856
Molecular Function	GO:0019894	kinesin binding	ISO	J:155856
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	TAS	J:70296
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	TAS	J:70122
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:180496
Molecular Function	GO:0005515	protein binding	IPI	J:273584
Molecular Function	GO:0005515	protein binding	IPI	J:247396
Molecular Function	GO:0005515	protein binding	IPI	J:212819
Molecular Function	GO:0005515	protein binding	IPI	J:116426
Molecular Function	GO:0005515	protein binding	IPI	J:102174
Molecular Function	GO:0005515	protein binding	IPI	J:102174
Molecular Function	GO:0038025	reelin receptor activity	IMP	J:142541
Molecular Function	GO:0030229	very-low-density lipoprotein particle receptor activity	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0005901	caveola	IBA	J:265628
Cellular Component	GO:0009986	cell surface	IDA	J:102174
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:131467
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005875	microtubule associated complex	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	TAS	J:70122
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0021541	ammon gyrus development	IMP	J:142541
Biological Process	GO:0007268	chemical synaptic transmission	IMP	J:142541
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:142541
Biological Process	GO:0006897	endocytosis	ISO	J:164563
Biological Process	GO:0021766	hippocampus development	IGI	J:129338
Biological Process	GO:0021819	layer formation in cerebral cortex	IGI	J:129338
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:142541
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	IMP	J:184736
Biological Process	GO:1900006	positive regulation of dendrite development	IGI	J:142541
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	IMP	J:184736
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:184736
Biological Process	GO:0045860	positive regulation of protein kinase activity	IGI	J:109819
Biological Process	GO:0045860	positive regulation of protein kinase activity	IGI	J:109819
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	IMP	J:184736
Biological Process	GO:0038026	reelin-mediated signaling pathway	IMP	J:142541
Biological Process	GO:0038026	reelin-mediated signaling pathway	IMP	J:184736
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:266110
Biological Process	GO:0045088	regulation of innate immune response	IMP	J:266110
Biological Process	GO:0021517	ventral spinal cord development	IEP	J:166792
Biological Process	GO:0021517	ventral spinal cord development	IBA	J:265628