GO Annotations Graph

• Symbol: Tlr6
• Name: toll-like receptor 6
• ID: MGI:1341296

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042498	diacyl lipopeptide binding	IDA	J:156189
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0071723	lipopeptide binding	IMP	J:70578
Molecular Function	GO:0071723	lipopeptide binding	ISO	J:155856
Molecular Function	GO:0071723	lipopeptide binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:156189
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0035663	Toll-like receptor 2 binding	ISO	J:164563
Molecular Function	GO:0035663	Toll-like receptor 2 binding	IBA	J:265628
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex	ISO	J:164563
Cellular Component	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex	IBA	J:265628
Cellular Component	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex	IDA	J:156189
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:0071726	cellular response to diacyl bacterial lipopeptide	IBA	J:265628
Biological Process	GO:0071726	cellular response to diacyl bacterial lipopeptide	ISO	J:73065
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	IGI	J:158401
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	ISO	J:164563
Biological Process	GO:0042496	detection of diacyl bacterial lipopeptide	ISO	J:73065
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	ISO	J:155856
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IGI	J:158401
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IGI	J:180762
Biological Process	GO:0046209	nitric oxide metabolic process	ISO	J:155856
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IGI	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:158401
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:73065
Biological Process	GO:0050729	positive regulation of inflammatory response	IGI	J:158401
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:205721
Biological Process	GO:0032735	positive regulation of interleukin-12 production	NAS	J:135494
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISS	J:103395
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:73065
Biological Process	GO:0043032	positive regulation of macrophage activation	IGI	J:158401
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IGI	J:158401
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:205721
Biological Process	GO:1903223	positive regulation of oxidative stress-induced neuron death	IGI	J:158401
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	IMP	J:158401
Biological Process	GO:0001817	regulation of cytokine production	IEA	J:72247
Biological Process	GO:0032493	response to bacterial lipoprotein	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0034150	toll-like receptor 6 signaling pathway	IEA	J:72247
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:155856
Biological Process	GO:0002224	toll-like receptor signaling pathway	IBA	J:265628
Biological Process	GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	ISO	J:164563
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	IGI	J:158401