GO Annotations Graph

• Symbol: Hey1
• Name: hairy/enhancer-of-split related with YRPW motif 1
• ID: MGI:1341800

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISS	J:62860
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:175314
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:175435
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:101349
Molecular Function	GO:0042802	identical protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:175435
Molecular Function	GO:0005515	protein binding	IPI	J:101349
Molecular Function	GO:0005515	protein binding	IPI	J:139632
Molecular Function	GO:0005515	protein binding	IPI	J:177242
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:160230
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:185205
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:175314
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2065441
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008180
Cellular Component	GO:0005634	nucleus	IDA	J:175314
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:70797
Cellular Component	GO:0005634	nucleus	ISS	J:139632
Biological Process	GO:0009948	anterior/posterior axis specification	IGI	J:96337
Biological Process	GO:0009948	anterior/posterior axis specification	IGI	J:96337
Biological Process	GO:0009952	anterior/posterior pattern specification	IBA	J:265628
Biological Process	GO:0003180	aortic valve morphogenesis	IDA	J:261827
Biological Process	GO:0060842	arterial endothelial cell differentiation	IGI	J:89444
Biological Process	GO:0060840	artery development	IGI	J:96337
Biological Process	GO:0060840	artery development	IGI	J:96337
Biological Process	GO:0003190	atrioventricular valve formation	IMP	J:119923
Biological Process	GO:0003181	atrioventricular valve morphogenesis	IGI	J:133699
Biological Process	GO:0001568	blood vessel development	IGI	J:96337
Biological Process	GO:0001568	blood vessel development	IGI	J:96337
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	IGI	J:89444
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	IGI	J:133699
Biological Process	GO:0060411	cardiac septum morphogenesis	IMP	J:119923
Biological Process	GO:0003208	cardiac ventricle morphogenesis	IMP	J:133699
Biological Process	GO:0072359	circulatory system development	IBA	J:265628
Biological Process	GO:0072049	comma-shaped body morphogenesis	IEP	J:97734
Biological Process	GO:0035912	dorsal aorta morphogenesis	IGI	J:89444
Biological Process	GO:0003203	endocardial cushion morphogenesis	IGI	J:133699
Biological Process	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation	IGI	J:96337
Biological Process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	IGI	J:133699
Biological Process	GO:0090162	establishment of epithelial cell polarity	IGI	J:171468
Biological Process	GO:0090162	establishment of epithelial cell polarity	IGI	J:171468
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	IGI	J:171468
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	IGI	J:171468
Biological Process	GO:0060716	labyrinthine layer blood vessel development	IGI	J:89444
Biological Process	GO:0014031	mesenchymal cell development	IGI	J:133699
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0070168	negative regulation of biomineral tissue development	IDA	J:261827
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:101349
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:101495
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:185205
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:153555
Biological Process	GO:0045665	negative regulation of neuron differentiation	IBA	J:265628
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:261827
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:119923
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:101495
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:175314
Biological Process	GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	ISO	J:164563
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	ISO	J:164563
Biological Process	GO:0061314	Notch signaling involved in heart development	IMP	J:119923
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:64398
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:155856
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	TAS	J:97734
Biological Process	GO:0007219	Notch signaling pathway	IBA	J:265628
Biological Process	GO:0002076	osteoblast development	IGI	J:146013
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:133699
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IGI	J:146013
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IGI	J:146013
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:89444
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:133699
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:261827
Biological Process	GO:0003184	pulmonary valve morphogenesis	IGI	J:133699
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IGI	J:171468
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IGI	J:171468
Biological Process	GO:0045607	regulation of inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0045607	regulation of inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0050767	regulation of neurogenesis	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:2001212	regulation of vasculogenesis	IGI	J:89444
Biological Process	GO:0072087	renal vesicle development	IEP	J:97734
Biological Process	GO:0072050	S-shaped body morphogenesis	IEP	J:97734
Biological Process	GO:0036304	umbilical cord morphogenesis	IGI	J:89444
Biological Process	GO:0060675	ureteric bud morphogenesis	IEP	J:97734
Biological Process	GO:0001570	vasculogenesis	IGI	J:89444
Biological Process	GO:0060412	ventricular septum morphogenesis	IGI	J:133699
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	IGI	J:96337