GO Annotations Graph

• Symbol: Eif2ak3
• Name: eukaryotic translation initiation factor 2 alpha kinase 3
• ID: MGI:1341830

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0071074	eukaryotic initiation factor eIF2 binding	IC	J:124910
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	IMP	J:124910
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	ISO	J:164563
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	ISO	J:155856
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	IDA	J:51759
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:248236
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:201928
Molecular Function	GO:0005515	protein binding	IPI	J:200066
Molecular Function	GO:0005515	protein binding	IPI	J:201928
Molecular Function	GO:0005515	protein binding	IPI	J:201568
Molecular Function	GO:0005515	protein binding	IPI	J:149195
Molecular Function	GO:0005515	protein binding	IPI	J:277868
Molecular Function	GO:0005515	protein binding	IPI	J:85958
Molecular Function	GO:0004672	protein kinase activity	IBA	J:265628
Molecular Function	GO:0004672	protein kinase activity	IMP	J:94221
Molecular Function	GO:0004672	protein kinase activity	IDA	J:85958
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:51759
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0045182	translation regulator activity	TAS	J:171795
Cellular Component	GO:0005737	cytoplasm	IDA	J:73377
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:70005
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:85958
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:51759
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment	IDA	J:296095
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:62257
Biological Process	GO:0001525	angiogenesis	ISO	J:164563
Biological Process	GO:0030282	bone mineralization	IMP	J:76661
Biological Process	GO:0019722	calcium-mediated signaling	IMP	J:105342
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0070417	cellular response to cold	ISO	J:164563
Biological Process	GO:0042149	cellular response to glucose starvation	ISO	J:164563
Biological Process	GO:0042149	cellular response to glucose starvation	IMP	J:215862
Biological Process	GO:0002063	chondrocyte development	IMP	J:84818
Biological Process	GO:0036492	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	IMP	J:296095
Biological Process	GO:0036492	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0031018	endocrine pancreas development	ISO	J:164563
Biological Process	GO:0007029	endoplasmic reticulum organization	IMP	J:70005
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	ISO	J:164563
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	TAS	J:171795
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:51759
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IMP	J:99655
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:85958
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IMP	J:62257
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IMP	J:94221
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IMP	J:107108
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IMP	J:70005
Biological Process	GO:0006983	ER overload response	ISO	J:164563
Biological Process	GO:0045444	fat cell differentiation	IDA	J:141100
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:84818
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:70005
Biological Process	GO:0007595	lactation	IMP	J:141100
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:94221
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:195351
Biological Process	GO:0031642	negative regulation of myelination	IMP	J:99655
Biological Process	GO:0017148	negative regulation of translation	IMP	J:201568
Biological Process	GO:0017148	negative regulation of translation	TAS	J:171795
Biological Process	GO:0017148	negative regulation of translation	IMP	J:107108
Biological Process	GO:0017148	negative regulation of translation	IMP	J:62257
Biological Process	GO:0017148	negative regulation of translation	IGI	J:107108
Biological Process	GO:0017148	negative regulation of translation	IDA	J:51759
Biological Process	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	IDA	J:51759
Biological Process	GO:0032055	negative regulation of translation in response to stress	ISO	J:155856
Biological Process	GO:0001503	ossification	ISO	J:164563
Biological Process	GO:0031016	pancreas development	IMP	J:76661
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:51759
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:217285
Biological Process	GO:0036499	PERK-mediated unfolded protein response	IMP	J:296095
Biological Process	GO:0036499	PERK-mediated unfolded protein response	IMP	J:124910
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI	J:203180
Biological Process	GO:1904294	positive regulation of ERAD pathway	TAS	J:171795
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:124910
Biological Process	GO:1903788	positive regulation of glutathione biosynthetic process	IMP	J:218003
Biological Process	GO:0032092	positive regulation of protein binding	IMP	J:105342
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	IMP	J:85958
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	IMP	J:218003
Biological Process	GO:0009967	positive regulation of signal transduction	IDA	J:141100
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	IMP	J:215862
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	ISO	J:164563
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IMP	J:124910
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	IMP	J:215862
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:201568
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:51759
Biological Process	GO:0046777	protein autophosphorylation	IMP	J:94221
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:51759
Biological Process	GO:0006468	protein phosphorylation	IDA	J:82058
Biological Process	GO:0006468	protein phosphorylation	IMP	J:62257
Biological Process	GO:0006468	protein phosphorylation	IDA	J:85958
Biological Process	GO:0006468	protein phosphorylation	IMP	J:76661
Biological Process	GO:0006468	protein phosphorylation	IMP	J:94221
Biological Process	GO:0006468	protein phosphorylation	IMP	J:107108
Biological Process	GO:0006468	protein phosphorylation	IMP	J:70005
Biological Process	GO:0060734	regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IMP	J:99455
Biological Process	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0019217	regulation of fatty acid metabolic process	IMP	J:141100
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IMP	J:62257
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IDA	J:217285
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IMP	J:99455
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IMP	J:124910
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:218003
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:99455
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0006986	response to unfolded protein	IEA	J:60000
Biological Process	GO:0001501	skeletal system development	IMP	J:76661
Biological Process	GO:0032933	SREBP signaling pathway	IDA	J:141100
Biological Process	GO:0006412	translation	IDA	J:82058
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	IMP	J:296095