GO Annotations Graph

• Symbol: Nod1
• Name: nucleotide-binding oligomerization domain containing 1
• ID: MGI:1341839

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0050700	CARD domain binding	ISO	J:73065
Molecular Function	GO:0042802	identical protein binding	ISO	J:73065
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0038187	pattern recognition receptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:161279
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045335	phagocytic vesicle	IDA	J:287065
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:73065
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0071225	cellular response to muramyl dipeptide	ISO	J:164563
Biological Process	GO:0006952	defense response	RCA	J:84168
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IGI	J:132126
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:132126
Biological Process	GO:0016045	detection of bacterium	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IDA	J:132126
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:132126
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0032635	interleukin-6 production	IMP	J:132126
Biological Process	GO:0032635	interleukin-6 production	IGI	J:132126
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0007254	JNK cascade	IDA	J:132126
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:132126
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:132126
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:73065
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	IMP	J:159410
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:132126
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:73065
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:132126
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:132126
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IGI	J:132126
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IDA	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:132126
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	ISO	J:155856
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	IDA	J:132126
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:132126
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:132126
Biological Process	GO:1904417	positive regulation of xenophagy	IMP	J:178691
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0051403	stress-activated MAPK cascade	IDA	J:132126
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:132126
Biological Process	GO:0032640	tumor necrosis factor production	IGI	J:132126
Biological Process	GO:0098792	xenophagy	IMP	J:178691