GO Annotations Graph

• Symbol: Hhip
• Name: Hedgehog-interacting protein
• ID: MGI:1341847

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0097108	hedgehog family protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:53760
Molecular Function	GO:0005515	protein binding	IPI	J:53760
Molecular Function	GO:0005515	protein binding	IPI	J:53760
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:94269
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:53760
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:85472
Biological Process	GO:0009953	dorsal/ventral pattern formation	IGI	J:94269
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	IMP	J:81798
Biological Process	GO:0016525	negative regulation of angiogenesis	NAS	J:175193
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0009968	negative regulation of signal transduction	ISO	J:164563
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IDA	J:175193
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:81798
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IDA	J:53760
Biological Process	GO:0007405	neuroblast proliferation	IGI	J:94269
Biological Process	GO:0007405	neuroblast proliferation	IGI	J:94269
Biological Process	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	IMP	J:81798
Biological Process	GO:0007165	signal transduction	IDA	J:53760
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:53760