GO Annotations Graph

• Symbol: Tjp2
• Name: tight junction protein 2
• ID: MGI:1341872

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:58914
Molecular Function	GO:0005515	protein binding	IPI	J:196719
Molecular Function	GO:0005515	protein binding	IPI	J:108862
Molecular Function	GO:0005515	protein binding	IPI	J:227841
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:155856
Cellular Component	GO:0005923	bicellular tight junction	IBA	J:265628
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:73065
Cellular Component	GO:0030054	cell junction	IDA	J:81857
Cellular Component	GO:0030054	cell junction	IDA	J:81857
Cellular Component	GO:0009986	cell surface	ISO	J:73065
Cellular Component	GO:0044291	cell-cell contact zone	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:279948
Cellular Component	GO:0005911	cell-cell junction	IDA	J:227841
Cellular Component	GO:0005921	gap junction	ISO	J:73065
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IDA	J:279948
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:196719
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:136803
Cellular Component	GO:0005886	plasma membrane	IDA	J:136803
Cellular Component	GO:0005886	plasma membrane	IDA	J:77501
Cellular Component	GO:0005886	plasma membrane	IDA	J:81857
Cellular Component	GO:0070160	tight junction	IDA	J:230002
Cellular Component	GO:0070160	tight junction	IDA	J:308050
Biological Process	GO:0098609	cell-cell adhesion	IBA	J:265628
Biological Process	GO:0045216	cell-cell junction organization	IBA	J:265628
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	ISO	J:164563
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	IBA	J:265628
Biological Process	GO:0034109	homotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0050892	intestinal absorption	ISO	J:164563
Biological Process	GO:2001205	negative regulation of osteoclast development	IMP	J:196719
Biological Process	GO:1905605	positive regulation of blood-brain barrier permeability	ISO	J:164563
Biological Process	GO:1905605	positive regulation of blood-brain barrier permeability	IBA	J:265628
Biological Process	GO:0150105	protein localization to cell-cell junction	IBA	J:265628
Biological Process	GO:0090559	regulation of membrane permeability	ISO	J:164563
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	IMP	J:196719