Hey2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Hey2
hairy/enhancer-of-split related with YRPW motif 2
MGI:1341884

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IMP	J:121581
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:175191
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISS	J:62860
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:101349
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:175435
Molecular Function	GO:0005515	protein binding	IPI	J:175191
Molecular Function	GO:0005515	protein binding	IPI	J:101349
Molecular Function	GO:0005515	protein binding	IPI	J:175112
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:185205
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IPI	J:108520
Cellular Component	GO:0005737	cytoplasm	IDA	J:175314
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2065441
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008180
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:175314
Cellular Component	GO:0005634	nucleus	IDA	J:121581
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	ISS	J:58781
Cellular Component	GO:0017053	transcription repressor complex	ISO	J:164563
Biological Process	GO:0009948	anterior/posterior axis specification	IGI	J:96337
Biological Process	GO:0009948	anterior/posterior axis specification	IGI	J:96337
Biological Process	GO:0009952	anterior/posterior pattern specification	IBA	J:265628
Biological Process	GO:0003180	aortic valve morphogenesis	IDA	J:261827
Biological Process	GO:0060842	arterial endothelial cell differentiation	IGI	J:89444
Biological Process	GO:0060840	artery development	IGI	J:96337
Biological Process	GO:0060840	artery development	IGI	J:96337
Biological Process	GO:0035910	ascending aorta morphogenesis	IMP	J:79025
Biological Process	GO:0060413	atrial septum morphogenesis	IMP	J:79025
Biological Process	GO:0003171	atrioventricular valve development	IMP	J:97120
Biological Process	GO:0001568	blood vessel development	IGI	J:96337
Biological Process	GO:0001568	blood vessel development	IGI	J:96337
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	IGI	J:89444
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	IMP	J:133699
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	IMP	J:79025
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	IMP	J:160578
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:133798
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:133798
Biological Process	GO:0003300	cardiac muscle hypertrophy	IMP	J:160578
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	IDA	J:108520
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	IMP	J:79025
Biological Process	GO:0060411	cardiac septum morphogenesis	IMP	J:119923
Biological Process	GO:0060948	cardiac vascular smooth muscle cell development	IMP	J:165754
Biological Process	GO:0003208	cardiac ventricle morphogenesis	IMP	J:101349
Biological Process	GO:0045165	cell fate commitment	IMP	J:144981
Biological Process	GO:0072359	circulatory system development	IBA	J:265628
Biological Process	GO:0090102	cochlea development	IMP	J:135642
Biological Process	GO:0090102	cochlea development	IGI	J:135642
Biological Process	GO:0090102	cochlea development	IGI	J:135642
Biological Process	GO:0060977	coronary vasculature morphogenesis	IMP	J:165754
Biological Process	GO:0035912	dorsal aorta morphogenesis	IGI	J:89444
Biological Process	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation	IGI	J:96337
Biological Process	GO:0060347	heart trabecula formation	IMP	J:119923
Biological Process	GO:0060716	labyrinthine layer blood vessel development	IGI	J:89444
Biological Process	GO:0014031	mesenchymal cell development	IMP	J:133699
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0003150	muscular septum morphogenesis	IMP	J:79025
Biological Process	GO:0070168	negative regulation of biomineral tissue development	IDA	J:261827
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IMP	J:160578
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:101349
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:175191
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:101495
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:185205
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:160578
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IDA	J:175159
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IMP	J:121581
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:101495
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:175314
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:261827
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:119923
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:60859
Biological Process	GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	IDA	J:175159
Biological Process	GO:0060633	negative regulation of transcription initiation by RNA polymerase II	ISO	J:164563
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	ISO	J:164563
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	IDA	J:175159
Biological Process	GO:0061314	Notch signaling involved in heart development	IC	J:79025
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:155856
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:64398
Biological Process	GO:0007219	Notch signaling pathway	IBA	J:265628
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:79025
Biological Process	GO:0007389	pattern specification process	IGI	J:135642
Biological Process	GO:0007389	pattern specification process	IGI	J:135642
Biological Process	GO:0007389	pattern specification process	IMP	J:135642
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IMP	J:133798
Biological Process	GO:0010460	positive regulation of heart rate	IMP	J:97120
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:89444
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:133699
Biological Process	GO:0065004	protein-DNA complex assembly	IDA	J:60859
Biological Process	GO:0065004	protein-DNA complex assembly	IDA	J:108520
Biological Process	GO:0061156	pulmonary artery morphogenesis	IMP	J:79025
Biological Process	GO:0003184	pulmonary valve morphogenesis	IMP	J:79025
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	IMP	J:165754
Biological Process	GO:0045607	regulation of inner ear auditory receptor cell differentiation	IGI	J:144981
Biological Process	GO:0050767	regulation of neurogenesis	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISS	J:58781
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISS	J:58781
Biological Process	GO:2001212	regulation of vasculogenesis	IGI	J:89444
Biological Process	GO:0003195	tricuspid valve formation	IMP	J:97120
Biological Process	GO:0003186	tricuspid valve morphogenesis	IMP	J:79025
Biological Process	GO:0036304	umbilical cord morphogenesis	IGI	J:89444
Biological Process	GO:0001570	vasculogenesis	IGI	J:89444
Biological Process	GO:0055015	ventricular cardiac muscle cell development	IMP	J:133798
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:79025
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	IGI	J:96337

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24