GO Annotations Graph

• Symbol: Klf4
• Name: Kruppel-like transcription factor 4 (gut)
• ID: MGI:1342287

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:185349
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:297718
Molecular Function	GO:0003677	DNA binding	ISS	J:97532
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:185349
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:197001
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:118301
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:281187
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0035014	phosphatidylinositol 3-kinase regulator activity	ISO	J:155856
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:168284
Molecular Function	GO:0005515	protein binding	IPI	J:259707
Molecular Function	GO:0005515	protein binding	IPI	J:245256
Molecular Function	GO:0005515	protein binding	IPI	J:260004
Molecular Function	GO:0005515	protein binding	IPI	J:240581
Molecular Function	GO:0005515	protein binding	IPI	J:297718
Molecular Function	GO:0005515	protein binding	IPI	J:211513
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:185349
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0001010	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	IDA	J:168300
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:168300
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:206059
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:37154
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:197001
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:168201
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:211513
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:155856
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:206059
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0000791	euchromatin	IDA	J:185349
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9625422
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	NAS	J:45178
Cellular Component	GO:0005634	nucleus	IPI	J:297718
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IDA	J:211513
Cellular Component	GO:0005634	nucleus	IDA	J:206059
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:185349
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:155856
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:185349
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0071499	cellular response to laminar fluid shear stress	ISO	J:164563
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0002357	defense response to tumor cell	ISO	J:164563
Biological Process	GO:0006351	DNA-templated transcription	IMP	J:195792
Biological Process	GO:0009913	epidermal cell differentiation	IMP	J:56495
Biological Process	GO:0009913	epidermal cell differentiation	IMP	J:56495
Biological Process	GO:0008544	epidermis development	IMP	J:297718
Biological Process	GO:0048730	epidermis morphogenesis	IMP	J:56495
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:297718
Biological Process	GO:0045444	fat cell differentiation	IMP	J:168300
Biological Process	GO:0045444	fat cell differentiation	IMP	J:197001
Biological Process	GO:0010467	gene expression	IMP	J:235073
Biological Process	GO:0010467	gene expression	IMP	J:297718
Biological Process	GO:0002067	glandular epithelial cell differentiation	IMP	J:117671
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	IMP	J:189337
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IDA	J:34906
Biological Process	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	ISO	J:164563
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IMP	J:206059
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NAS	J:45178
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISS	J:45178
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:1904998	negative regulation of leukocyte adhesion to arterial endothelial cell	ISO	J:164563
Biological Process	GO:0014740	negative regulation of muscle hyperplasia	ISO	J:155856
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0060761	negative regulation of response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:1904798	positive regulation of core promoter binding	IMP	J:185349
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:168201
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:168284
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0046985	positive regulation of hemoglobin biosynthetic process	ISO	J:164563
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:185349
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:281188
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:168300
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:197001
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:211513
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:117671
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:117671
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:118301
Biological Process	GO:0031077	post-embryonic camera-type eye development	IMP	J:117671
Biological Process	GO:0031077	post-embryonic camera-type eye development	IMP	J:117671
Biological Process	GO:0031077	post-embryonic camera-type eye development	IMP	J:117671
Biological Process	GO:0035166	post-embryonic hemopoiesis	ISO	J:164563
Biological Process	GO:0048679	regulation of axon regeneration	IGI	J:206059
Biological Process	GO:0048679	regulation of axon regeneration	IMP	J:206059
Biological Process	GO:0120222	regulation of blastocyst development	IMP	J:259707
Biological Process	GO:0045595	regulation of cell differentiation	IDA	J:168284
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:123915
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:154112
Biological Process	GO:0010033	response to organic substance	IDA	J:136286
Biological Process	GO:0032526	response to retinoic acid	IDA	J:136286
Biological Process	GO:0035019	somatic stem cell population maintenance	IDA	J:96515
Biological Process	GO:0019827	stem cell population maintenance	IDA	J:168284
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:197001