GO Annotations Graph

• Symbol: Lat
• Name: linker for activation of T cells
• ID: MGI:1342293

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:209882
Molecular Function	GO:0005515	protein binding	IPI	J:186446
Molecular Function	GO:0005515	protein binding	IPI	J:172064
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0008180	COP9 signalosome	IDA	J:186446
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0001772	immunological synapse	ISO	J:164563
Cellular Component	GO:0001772	immunological synapse	IDA	J:90603
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	J:49412
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0006968	cellular defense response	TAS	J:49412
Biological Process	GO:0010467	gene expression	IMP	J:100686
Biological Process	GO:0048872	homeostasis of number of cells	IMP	J:205441
Biological Process	GO:0006955	immune response	ISO	J:164563
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IMP	J:100686
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0002260	lymphocyte homeostasis	IMP	J:205449
Biological Process	GO:0043303	mast cell degranulation	IEA	J:60000
Biological Process	GO:0045860	positive regulation of protein kinase activity	IBA	J:265628
Biological Process	GO:0007265	Ras protein signal transduction	ISO	J:164563
Biological Process	GO:0050863	regulation of T cell activation	ISO	J:164563
Biological Process	GO:0050863	regulation of T cell activation	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0050852	T cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	J:54183