GO Annotations Graph

• Symbol: Spop
• Name: speckle-type BTB/POZ protein
• ID: MGI:1343085

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:248252
Molecular Function	GO:0005515	protein binding	IPI	J:201256
Molecular Function	GO:0005515	protein binding	IPI	J:89879
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:151923
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:151923
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0016607	nuclear speck	IDA	J:89879
Cellular Component	GO:0016607	nuclear speck	IDA	J:151923
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0042593	glucose homeostasis	IGI	J:165286
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IGI	J:165268
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IGI	J:165268
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IDA	J:89879
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:89879
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI	J:165268
Biological Process	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	IGI	J:165286
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IGI	J:165268
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0030162	regulation of proteolysis	IBA	J:265628
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	IGI	J:165286
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	IGI	J:165286
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:151923