GO Annotations Graph

• Symbol: Pdk2
• Name: pyruvate dehydrogenase kinase, isoenzyme 2
• ID: MGI:1343087

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	ISO	J:164563
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	IMP	J:185475
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	ISO	J:155856
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	IDA	J:168464
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:168464
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	ISO	J:155856
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:60000
Biological Process	GO:0031670	cellular response to nutrient	IMP	J:185475
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IMP	J:185475
Biological Process	GO:0006006	glucose metabolic process	IEA	J:60000
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:185475
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	IMP	J:185475
Biological Process	GO:0050848	regulation of calcium-mediated signaling	IMP	J:195164
Biological Process	GO:0010565	regulation of cellular ketone metabolic process	IMP	J:185475
Biological Process	GO:0006111	regulation of gluconeogenesis	IMP	J:185475
Biological Process	GO:0010906	regulation of glucose metabolic process	IMP	J:185475
Biological Process	GO:0010906	regulation of glucose metabolic process	IBA	J:265628
Biological Process	GO:0006885	regulation of pH	IMP	J:185475