GO Annotations Graph

• Symbol: Hdac3
• Name: histone deacetylase 3
• ID: MGI:1343091

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:210667
Molecular Function	GO:0003682	chromatin binding	IDA	J:98847
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:297718
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:136678
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0019213	deacetylase activity	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IDA	J:96189
Molecular Function	GO:0003677	DNA binding	IDA	J:88316
Molecular Function	GO:0140297	DNA-binding transcription factor binding	TAS	J:113927
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0004857	enzyme inhibitor activity	ISO	J:164563
Molecular Function	GO:0051020	GTPase binding	ISO	J:155856
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:164563
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:155856
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:319948
Molecular Function	GO:0004407	histone deacetylase activity	TAS	J:113927
Molecular Function	GO:0004407	histone deacetylase activity	IBA	J:265628
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:139241
Molecular Function	GO:0004407	histone deacetylase activity	IMP	J:98847
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0160009	histone decrotonylase activity	ISO	J:164563
Molecular Function	GO:0160009	histone decrotonylase activity	IDA	J:319948
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:116423
Molecular Function	GO:0005515	protein binding	IPI	J:203745
Molecular Function	GO:0005515	protein binding	IPI	J:162637
Molecular Function	GO:0005515	protein binding	IPI	J:240095
Molecular Function	GO:0005515	protein binding	IPI	J:248212
Molecular Function	GO:0005515	protein binding	IPI	J:297718
Molecular Function	GO:0005515	protein binding	IPI	J:102172
Molecular Function	GO:0005515	protein binding	IPI	J:76212
Molecular Function	GO:0005515	protein binding	IPI	J:241450
Molecular Function	GO:0005515	protein binding	IPI	J:154803
Molecular Function	GO:0005515	protein binding	IPI	J:102172
Molecular Function	GO:0005515	protein binding	IPI	J:142342
Molecular Function	GO:0005515	protein binding	IPI	J:129966
Molecular Function	GO:0005515	protein binding	IPI	J:72326
Molecular Function	GO:0160010	protein de-2-hydroxyisobutyrylase activity	ISO	J:164563
Molecular Function	GO:0160008	protein decrotonylase activity	ISO	J:164563
Molecular Function	GO:0033558	protein lysine deacetylase activity	ISO	J:164563
Molecular Function	GO:0033558	protein lysine deacetylase activity	IDA	J:210667
Molecular Function	GO:0033558	protein lysine deacetylase activity	IDA	J:241450
Molecular Function	GO:0033558	protein lysine deacetylase activity	IDA	J:118246
Molecular Function	GO:0033558	protein lysine deacetylase activity	IDA	J:118246
Molecular Function	GO:0033558	protein lysine deacetylase activity	IDA	J:118246
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IDA	J:118246
Molecular Function	GO:0008134	transcription factor binding	IDA	J:118246
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:240095
Cellular Component	GO:0005737	cytoplasm	TAS	J:113927
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:118246
Cellular Component	GO:0005737	cytoplasm	IDA	J:241450
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:241450
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0000118	histone deacetylase complex	ISO	J:164563
Cellular Component	GO:0000118	histone deacetylase complex	TAS	J:113927
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-442515
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-556760
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617990
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5667077
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008136
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9005747
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9005752
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	TAS	J:113927
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:240095
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IPI	J:297718
Cellular Component	GO:0005634	nucleus	IDA	J:118246
Cellular Component	GO:0005634	nucleus	ISO	J:241450
Cellular Component	GO:0005634	nucleus	IDA	J:196753
Cellular Component	GO:0005634	nucleus	IDA	J:241450
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0017053	transcription repressor complex	ISO	J:164563
Biological Process	GO:0071498	cellular response to fluid shear stress	ISO	J:164563
Biological Process	GO:0006325	chromatin organization	TAS	J:113927
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:240095
Biological Process	GO:0032922	circadian regulation of gene expression	IGI	J:142342
Biological Process	GO:1903575	cornified envelope assembly	IMP	J:297718
Biological Process	GO:0008544	epidermis development	IMP	J:297718
Biological Process	GO:0000132	establishment of mitotic spindle orientation	ISO	J:164563
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:297718
Biological Process	GO:0010467	gene expression	IMP	J:297718
Biological Process	GO:0016575	histone deacetylation	IBA	J:265628
Biological Process	GO:0001701	in utero embryonic development	IMP	J:297718
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	IMP	J:210667
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IDA	J:210667
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0032692	negative regulation of interleukin-1 production	ISO	J:155856
Biological Process	GO:0046329	negative regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0046826	negative regulation of protein export from nucleus	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:210667
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:118246
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:154803
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:249650
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IMP	J:240095
Biological Process	GO:0032008	positive regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	ISO	J:155856
Biological Process	GO:0006476	protein deacetylation	ISO	J:164563
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:240095
Biological Process	GO:0007346	regulation of mitotic cell cycle	IDA	J:58415
Biological Process	GO:0040014	regulation of multicellular organism growth	IGI	J:142342
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0051225	spindle assembly	ISO	J:164563
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:154803
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:210667